Gene

hif1al

ID

ZDB-GENE-040426-1315

Name

hypoxia inducible factor 1 subunit alpha, like

Symbol

hif1al Nomenclature History

Previous Names

hif-3 (1)
Hif3a (1)
Hif-3 alpha (1)
zgc:63965

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Exhibits beta-catenin binding activity and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including neuron apoptotic process; response to activity; and response to hypoxia. Localizes to beta-catenin-TCF complex. Is expressed in several structures, including digestive system; head; heart; inner ear; and pleuroperitoneal region. Orthologous to human HIF3A (hypoxia inducible factor 3 subunit alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

19 figures from 15 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63965 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hif1al Human Ortholog

No data available

Associated With hif1al Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000014	PAS domain
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR013767	PAS fold
Domain	IPR021537	Hypoxia-inducible factor, alpha subunit-like
Family	IPR001067	Nuclear translocator
Homologous_superfamily	IPR035965	PAS domain superfamily
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily
Repeat	IPR001610	PAC motif

Domain Details Per Protein

Protein	Length	Helix-loop-helix DNA-binding domain superfamily	Hypoxia-inducible factor, alpha subunit-like	Myc-type, basic helix-loop-helix (bHLH) domain	Nuclear translocator	PAC motif	PAS domain	PAS domain superfamily	PAS fold
UniProtKB:Q7T2E4 InterPro	571
UniProtKB:A0A8M9QBW4 InterPro	564
UniProtKB:A0A0R4IB28 InterPro	619
UniProtKB:A0A0R4IBR4 InterPro	626

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hif1al-201 (1) Ensembl	Ensembl	900 nt	Select Tool
mRNA	hif1al-202 (1) Ensembl	Ensembl	5,161 nt	Select Tool ZFIN BLAST
mRNA	hif1al-203 (1) Ensembl	Ensembl	3,185 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-hif1al	polyclonal	hif1al		Rabbit	WB		4

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations