Gene
scarb1
- ID
- ZDB-GENE-031126-1
- Name
- scavenger receptor class B, member 1
- Symbol
- scarb1 Nomenclature History
- Previous Names
-
- cb1015 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable lipid binding activity; low-density lipoprotein particle binding activity; and scavenger receptor activity. Predicted to be involved in cholesterol transport; plasma lipoprotein particle clearance; and recognition of apoptotic cell. Predicted to be located in membrane. Predicted to be active in caveola and cytoplasm. Is expressed in intestine; segmental plate; somite; xanthophore; and yolk syncytial layer. Orthologous to human SCARB1 (scavenger receptor class B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1015 (5 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [High density lipoprotein cholesterol level QTL6] | 610762 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CD36 family | CD36/scavenger receptor class B member 1 |
|---|---|---|---|
|
UniProtKB:A0A8M6Z8R4
|
511 | ||
|
UniProtKB:A0A0R4IRL8
|
496 | ||
|
UniProtKB:A0A0R4IQE0
|
505 | ||
|
UniProtKB:A0A0R4IDW0
|
492 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
scarb1-206
(1)
|
Ensembl | 844 nt | ||
| mRNA | scarb1-001_dup (1) | 1,491 nt | |||
| mRNA |
scarb1-201
(1)
|
Ensembl | 773 nt | ||
| mRNA |
scarb1-202
(1)
|
Ensembl | 4,451 nt | ||
| mRNA |
scarb1-203
(1)
|
Ensembl | 436 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-226M13 | Sanger(Havana Group) and ZFIN Staff | |
| Encodes | EST | cb1015 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:55861 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198921 (1) | 2612 nt | ||
| Genomic | GenBank:CU463283 (1) | 121463 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z8R4 (1) | 511 aa |
- Gora, A.H., Rehman, S., Dias, J., Fernandes, J.M.O., Olsvik, P.A., Sørensen, M., Kiron, V. (2023) Protective mechanisms of a microbial oil against hypercholesterolemia: evidence from a zebrafish model. Frontiers in nutrition. 10:11611191161119
- Verwilligen, R.A.F., Mulder, L., Araújo, P.M., Carneiro, M., Bussmann, J., Hoekstra, M., Van Eck, M. (2023) Zebrafish as outgroup model to study evolution of scavenger receptor class B type I functions. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1868(6):159308
- Verwilligen, R.A.F., Mulder, L., Rodenburg, F.J., Van Dijke, A., Hoekstra, M., Bussmann, J., Van Eck, M. (2022) Stabilin 1 and 2 are important regulators for cellular uptake of apolipoprotein B-containing lipoproteins in zebrafish. Atherosclerosis. 346:18-25
- Meng, H., Shang, Y., Cheng, Y., Wang, K., Yu, J., Cao, P., Fan, S., Li, Y., Cui, J. (2021) Knockout of zebrafish colony-stimulating factor 1 receptor by CRISPR/Cas9 affects metabolism and locomotion capacity. Biochemical and Biophysical Research Communications. 551:93-99
- Sulliman, N.C., Ghaddar, B., Gence, L., Patche, J., Rastegar, S., Meilhac, O., Diotel, N. (2021) HDL biodistribution and brain receptors in zebrafish, using HDLs as vectors for targeting endothelial cells and neural progenitors. Scientific Reports. 11:6439
- Watt, A.T., Head, B., Leonard, S.W., Tanguay, R.L., Traber, M.G. (2021) Gene Expression of CRAL_TRIO Family Proteins modulated by Vitamin E Deficiency in Zebrafish (Danio Rerio). The Journal of Nutritional Biochemistry. 97:108801
- Gur, D., Bain, E.J., Johnson, K.R., Aman, A.J., Pasoili, H.A., Flynn, J.D., Allen, M.C., Deheyn, D.D., Lee, J.C., Lippincott-Schwartz, J., Parichy, D.M. (2020) In situ differentiation of iridophore crystallotypes underlies zebrafish stripe patterning. Nature communications. 11:6391
- Zhao, Y., Cao, X., Fu, L., Gao, J. (2020) n-3 PUFA reduction caused by fabp2 deletion interferes with triacylglycerol metabolism and cholesterol homeostasis in fish. Applied Microbiology and Biotechnology. 104(5):2149-2161
- Lewis, V.M., Saunders, L.M., Larson, T.A., Bain, E.J., Sturiale, S.L., Gur, D., Chowdhury, S., Flynn, J.D., Allen, M.C., Deheyn, D.D., Lee, J.C., Simon, J.A., Lippincott-Schwartz, J., Raible, D.W., Parichy, D.M. (2019) Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores. Proceedings of the National Academy of Sciences of the United States of America. 116(24):11806-11811
- Lin, X., Zhou, Q., Zhao, C., Lin, G., Xu, J., Wen, Z. (2019) An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis. Developmental Cell. 49(4):605-617.e5
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