Gene

padi2

ID

ZDB-GENE-031116-67

Name

peptidyl arginine deiminase, type II

Symbol

padi2 Nomenclature History

Previous Names

sb:cb968
zgc:66317

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have protein-arginine deiminase activity. Involved in vasculature development. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in infertility and rheumatoid arthritis. Is expressed in epidermis; pectoral fin musculature; periderm; pharynx; and sensory system. Orthologous to several human genes including PADI2 (peptidyl arginine deiminase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

19 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb968 (9 images)
IMAGE:6903054 (6 images)
IMAGE:7158214 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With padi2 Human Ortholog

No data available

Associated With padi2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013530	Protein-arginine deiminase, C-terminal
Domain	IPR013732	Protein-arginine deiminase (PAD), N-terminal
Domain	IPR013733	Protein-arginine deiminase (PAD), central domain
Family	IPR004303	Protein-arginine deiminase
Homologous_superfamily	IPR008972	Cupredoxin
Homologous_superfamily	IPR036556	Protein-arginine deiminase, central domain superfamily
Homologous_superfamily	IPR038685	PAD, N-terminal domain superfamily