Gene
fscn1a
- ID
- ZDB-GENE-031009-1
- Name
- fascin actin-bundling protein 1a
- Symbol
- fscn1a Nomenclature History
- Previous Names
-
- fscn1
- sb:cb589
- zgc:153632
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables actin filament binding activity; protein-macromolecule adaptor activity; and signaling receptor binding activity. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; epiboly; and neural crest cell migration involved in sympathetic nervous system development. Predicted to be located in cytoskeleton. Predicted to be active in several cellular components, including lamellipodium; microvillus; and ruffle. Is expressed in several structures, including head; mesoderm; nervous system; neural crest; and neural plate. Orthologous to human FSCN1 (fascin actin-bundling protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb589 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ioz6 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ioz100 | Allele with one delins | Exon 1 | Frameshift, Premature Stop | TALEN | |
| la024199Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa44571 | Allele with one point mutation | Unknown | Unknown | ENU | |
| zd1011 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
| zd1012 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
| zd1013 | Allele with one delins | Unknown | Frameshift, Premature Stop | TALEN |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Actin-crosslinking | Fascin | Fascin domain | Fascin, metazoans |
|---|---|---|---|---|---|
|
UniProtKB:Q08C47
|
491 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fscn1a-201
(1)
|
Ensembl | 3,077 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-fscn1 | monoclonal | IgG | Rabbit |
|
Epitomics, Inc
|
3 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-255L18 | ZFIN Curated Data | |
| Encodes | EST | cb589 | Thisse et al., 2001 | |
| Encodes | EST | wz2126 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153632 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192701 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001076560 (1) | 2495 nt | ||
| Genomic | GenBank:AL929031 (1) | 187548 nt | ||
| Polypeptide | UniProtKB:Q08C47 (1) | 491 aa |
- Chestnut, B., Casie Chetty, S., Koenig, A.L., Sumanas, S. (2020) Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle. Nature communications. 11:2796
- Kondrychyn, I., Kelly, D.J., Carretero, N.T., Nomori, A., Kato, K., Chong, J., Nakajima, H., Okuda, S., Mochizuki, N., Phng, L.K. (2020) Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size. Nature communications. 11:5476
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Nittoli, V., Fortunato, A.E., Fasano, G., Coppola, U., Gentile, A., Maiella, S., Langellotto, F., Porreca, I., De Paolo, R., Marino, R., Fiengo, M., Donizetti, A., Aniello, F., Kondo, T., Ristoratore, F., Canzoniero, L.M.T., Duboule, D., Wilson, S.W., Sordino, P. (2019) Characterization of paralogous uncx transcription factor encoding genes in zebrafish. Gene X. 2:100011
- Rutherford, N.E., Wong, A.H., Bruce, A.E.E. (2019) Spatio-temporal characterization of dynamic epithelial filopodia during zebrafish epiboly. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(10):997-1008
- Witjes, L., Van Troys, M., Vandekerckhove, J., Vandepoele, K., Ampe, C. (2019) A new evolutionary model for the vertebrate actin family including two novel groups. Molecular phylogenetics and evolution. 141:106632
- Almuedo-Castillo, M., Bläßle, A., Mörsdorf, D., Marcon, L., Soh, G.H., Rogers, K.W., Schier, A.F., Müller, P. (2018) Scale-invariant patterning by size-dependent inhibition of Nodal signalling. Nature cell biology. 20(9):1032-1042
- Wu, X., Shen, W., Zhang, B., Meng, A. (2018) The genetic program of oocytes can be modified in vivo in the zebrafish ovary. Journal of molecular cell biology. 10(6):479-493
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wei, S., Ning, G., Li, L., Yan, Y., Yang, S., Cao, Y., Wang, Q. (2017) A GEF activity-independent function for nuclear Net1 in Nodal/Smad2 signal transduction and mesendoderm formation. Journal of Cell Science. 130(18):3072-3082
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