Gene

gad1b

ID

ZDB-GENE-030909-3

Name

glutamate decarboxylase 1b

Symbol

gad1b Nomenclature History

Previous Names

gad1
GAD67 (1)
gad67 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable glutamate decarboxylase activity. Acts upstream of or within gamma-aminobutyric acid biosynthetic process and neurotransmitter biosynthetic process. Predicted to be active in cytoplasm and presynaptic active zone. Is expressed in nervous system and neural tube. Used to study epilepsy. Human ortholog(s) of this gene implicated in anxiety disorder; bipolar disorder; developmental and epileptic encephalopathy 89; and schizophrenia. Orthologous to human GAD1 (glutamate decarboxylase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

115 figures from 76 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56253 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gad1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 89	Alliance	Developmental and epileptic encephalopathy 89	619124

Associated With gad1b Via Experimental Models

Human Disease	Fish	Conditions	Citations
epilepsy	gad1b^{ga2303/ga2303} (WIK)	standard conditions	O'Connor et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR021115	Pyridoxal-phosphate binding site
Family	IPR002129	Pyridoxal phosphate-dependent decarboxylase
Homologous_superfamily	IPR015421	Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily	IPR015424	Pyridoxal phosphate-dependent transferase

Domain Details Per Protein

Protein	Length	Pyridoxal-phosphate binding site	Pyridoxal phosphate-dependent decarboxylase	Pyridoxal phosphate-dependent transferase	Pyridoxal phosphate-dependent transferase, major domain
UniProtKB:Q7ZUS3 InterPro	587
UniProtKB:A0A2R8QPB1 InterPro	566

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gad1b-201 (1) Ensembl	Ensembl	3,404 nt	Select Tool ZFIN BLAST
mRNA	gad1b-202 (1) Ensembl	Ensembl	3,483 nt	Select Tool ZFIN BLAST
mRNA	gad1b-205 (1) Ensembl	Ensembl	4,575 nt	Select Tool ZFIN BLAST
mRNA	gad1b-206 (1) Ensembl	Ensembl	4,512 nt	Select Tool ZFIN BLAST
ncRNA	gad1b-002 (1) Ensembl	Ensembl	585 nt	Select Tool ZFIN BLAST
ncRNA	gad1b-003 (1) Ensembl	Ensembl	793 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-gad1	polyclonal	gad1b		Rabbit	IHC WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations