Gene
paqr7b
- ID
- ZDB-GENE-030728-2
- Name
- progestin and adipoQ receptor family member VII, b
- Symbol
- paqr7b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables nuclear steroid receptor activity and steroid binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and steroid hormone mediated signaling pathway. Acts upstream of or within oocyte maturation; response to steroid hormone; and signal transduction. Located in plasma membrane. Is expressed in several structures, including brain; gill; gonad; intestine; and sperm. Orthologous to human PAQR7 (progestin and adipoQ receptor family member 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ecu12 | Allele with one deletion | Exon 2 | Premature Stop | TALEN |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR004254 | AdipoR/Haemolysin-III-related |
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Domain Details Per Protein
| Protein | Length | AdipoR/Haemolysin-III-related |
|---|---|---|
|
UniProtKB:Q801G2
|
354 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
paqr7b-201
(1)
|
Ensembl | 1,403 nt | ||
| mRNA |
paqr7b-202
(1)
|
Ensembl | 1,396 nt | ||
| mRNA |
paqr7b-203
(1)
|
Ensembl | 474 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-255I3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_183345 (1) | 1478 nt | ||
| Genomic | GenBank:CR626886 (2) | 165396 nt | ||
| Polypeptide | UniProtKB:Q801G2 (1) | 354 aa |
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
- Hou, L., Chen, S., Shi, W., Chen, H., Liang, Y., Wang, X., Tan, J., Wang, Y., Deng, X., Zhan, M., Long, J., Cai, G., Luo, S., Zhang, C., Liu, J., Leung, J.Y.S., Xie, L. (2020) Norethindrone alters mating behaviors, ovary histology, hormone production and transcriptional expression of steroidogenic genes in zebrafish (Danio rerio). Ecotoxicology and environmental safety. 195:110496
- Li, M., Cao, J., Zhao, Y., Wu, P., Li, X., Khodaei, F., Han, Y., Wang, J. (2020) Fluoride impairs ovary development by affecting oogenesis and inducing oxidative stress and apoptosis in female zebrafish (Danio rerio). Chemosphere. 256:127105
- Lu, H., Zhao, C., Zhu, B., Zhang, Z., Ge, W. (2020) Loss of Inhibin Advances Follicle Activation and Female Puberty Onset but Blocks Oocyte Maturation in Zebrafish. Endocrinology. 161(12):
- Maradonna, F., Gioacchini, G., Notarstefano, V., Fontana, C.M., Citton, F., Dalla Valle, L., Giorgini, E., Carnevali, O. (2020) Knockout of the Glucocorticoid Receptor Impairs Reproduction in Female Zebrafish. International Journal of Molecular Sciences. 21(23):
- Wu, X.J., Liu, D.T., Chen, S., Hong, W., Zhu, Y. (2020) Impaired oocyte maturation and ovulation in membrane progestin receptor (mPR) knockouts in zebrafish. Molecular and Cellular Endocrinology. 511:110856
- Zayed, Y., Malik, R., Qi, X., Peng, C. (2020) Nodal regulates ovarian functions in zebrafish. Molecular and Cellular Endocrinology. 511:110821
- Liang, Y.Q., Huang, G.Y., Zhen, Z., Tian, F., Hou, L., Lin, Z., Ying, G.G. (2019) The effects of binary mixtures of estradiol and progesterone on transcriptional expression profiles of genes involved in hypothalamic-pituitary-gonadal axis and circadian rhythm signaling in embryonic zebrafish (Danio rerio). Ecotoxicology and environmental safety. 174:540-548
- Santangeli, S., Consales, C., Pacchierotti, F., Habibi, H.R., Carnevali, O. (2019) Transgenerational effects of BPA on female reproduction. The Science of the total environment. 685:1294-1305
- Wu, X.J., Jermaul Williams, M., Rameshkumar Patel, P., Ann Kew, K., Zhu, Y. (2019) Subfertility and reduced progestin synthesis in Pgrmc2 knockout zebrafish. General and comparative endocrinology. 282:113218
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