Gene
epb41l5
- ID
- ZDB-GENE-030616-450
- Name
- erythrocyte membrane protein band 4.1 like 5
- Symbol
- epb41l5 Nomenclature History
- Previous Names
-
- moe
- mosaic eyes
- si:dz104f18.2
- si:dz104f18.3
- si:dz37o5.2
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable cytoskeletal protein binding activity. Acts upstream of or within several processes, including eye morphogenesis; maintenance of epithelial cell apical/basal polarity; and positive regulation of Notch signaling pathway. Located in bicellular tight junction. Part of protein-containing complex. Is expressed in integument; nervous system; and pronephros. Used to study proteinuria. Orthologous to human EPB41L5 (erythrocyte membrane protein band 4.1 like 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b781 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| b882 | Allele with one point mutation | Donor Splice Site of Exon 5 | Intron Gain of Intron 5 | not specified | |
| epb41l5_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| la026880Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| rw170 | unknown | Unknown | Unknown | not specified | |
| rw306 | Allele with one point mutation | Unknown | Missense | ENU | |
| rw310 | unknown | Unknown | Unknown | not specified | |
| sa2498 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa7186 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9677 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| proteinuria | epb41l5b882/b882 (TU) | standard conditions | Kramer-Zucker et al., 2005 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Band 4.1 domain | Ezrin/radixin/moesin-like | FERM/acyl-CoA-binding protein superfamily | FERM adjacent | FERM central domain | FERM conserved site | FERM, C-terminal PH-like domain | FERM domain | FERM, N-terminal | FERM superfamily, second domain | PH-like domain superfamily | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NYK4
|
772 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | epb41l5-002 (1) | Havana | 2,557 nt | ||
| mRNA |
epb41l5-201
(1)
|
Ensembl | 5,070 nt | ||
| mRNA |
epb41l5-202
(1)
|
Ensembl | 4,081 nt | ||
| mRNA |
epb41l5-203
(1)
|
Ensembl | 2,331 nt | ||
| mRNA |
epb41l5-204
(1)
|
Ensembl | 1,939 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-epb41l5 | polyclonal | Rabbit |
|
2 | |||
| Ab2-epb41l5 | polyclonal | Guinea pig |
|
1 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-81J7 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-37O5 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-104F18 | ||
| Encodes | cDNA | MGC:77253 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200089 (1) | 4104 nt | ||
| Genomic | GenBank:AL935307 (1) | 234744 nt | ||
| Polypeptide | UniProtKB:Q6NYK4 (1) | 772 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | EPB41L5 | 2 | Amino acid sequence comparison (2) Conserved genome location (synteny) (2) | |
| Mouse | Epb41l5 | 1 | Conserved genome location (synteny) (1) Amino acid sequence comparison (1) | |
| Fruit fly | yrt | 3R | Conserved genome location (synteny) (1) Amino acid sequence comparison (1) |
- Horstick, E.J., Bayleyen, Y., Burgess, H.A. (2020) Molecular and cellular determinants of motor asymmetry in zebrafish. Nature communications. 11:1170
- Yu, T., Matsuda, M. (2020) Epb41l5 interacts with IQCB1 and regulates ciliary function in zebrafish embryos. Journal of Cell Science. 133(12):
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Matsuda, M., Rand, K., Palardy, G., Shimizu, N., Ikeda, H., Nogare, D.D., Itoh, M., Chitnis, A.B. (2016) Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons. Development (Cambridge, England). 143(17):3085-96
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Ohata, S., Aoki, R., Kinoshita, S., Yamaguchi, M., Tsuruoka-Kinoshita, S., Tanaka, H., Wada, H., Watabe, S., Tsuboi, T., Masai, I., and Okamoto, H. (2011) Dual Roles of Notch in Regulation of Apically Restricted Mitosis and Apicobasal Polarity of Neuroepithelial Cells. Neuron. 69(2):215-230
- Beyer, J., Zhao, X.C., Yee, R., Khaliq, S., McMahon, T.T., Ying, H., Yue, B.Y., and Malicki, J.J. (2010) The role of crumbs genes in the vertebrate cornea. Investigative ophthalmology & visual science. 51(9):4549-4556
- Hsu, Y.C., and Jensen, A.M. (2010) Multiple domains in the Crumbs Homolog 2a (Crb2a) protein are required for regulating rod photoreceptor size. BMC Cell Biology. 11:60
- Yamaguchi, M., Imai, F., Tonou-Fujimori, N., and Masai, I. (2010) Mutations in N-cadherin and a Stardust homolog, Nagie oko, affect cell-cycle exit in zebrafish retina. Mechanisms of Development. 127(5-6):247-264
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