Gene

itsn1

ID

ZDB-GENE-030616-226

Name

intersectin 1 (SH3 domain protein)

Symbol

itsn1 Nomenclature History

Previous Names

si:dz173a8.1

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in intracellular signal transduction. Orthologous to human ITSN1 (intersectin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Dergai et al., 2010

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With itsn1 Human Ortholog

No data available

Associated With itsn1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000008	C2 domain
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR000261	EH domain
Domain	IPR001452	SH3 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR002048	EF-hand domain
Domain	IPR032140	Intersectin-1, AP2 binding region
Family	IPR051480	Endocytic & GEF Adapter
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily

Domain Details Per Protein

Protein	Length	C2 domain	C2 domain superfamily	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	EF-Hand 1, calcium-binding site	EF-hand domain	EF-hand domain pair	EH domain	Endocytic & GEF Adapter	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	Intersectin-1, AP2 binding region	PH-like domain superfamily	Pleckstrin homology domain	SH3 domain	SH3-like domain superfamily
UniProtKB:A0A8M2BIA8 InterPro	1250
UniProtKB:Q8JFT4 InterPro	1721
UniProtKB:A0A8M2BI58 InterPro	1746
UniProtKB:A0A8M2BIP7 InterPro	1751

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	itsn1-002 (1)	Havana	4,622 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	itsn1-201 (1) Ensembl	Ensembl	5,681 nt	Select Tool
mRNA	itsn1-204 (1) Ensembl	Ensembl	5,191 nt	Select Tool ZFIN BLAST
mRNA	ottdart00000003965 (1)	Havana	5,197 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	itsn1-003 (1) Ensembl	Ensembl	644 nt	Select Tool
ncRNA	ottdart00000009539 (1) Ensembl	Ensembl	3,923 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations