Gene
p2rx7
- ID
- ZDB-GENE-030319-6
- Name
- purinergic receptor P2X, ligand-gated ion channel, 7
- Symbol
- p2rx7 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables extracellularly ATP-gated monoatomic cation channel activity. Acts upstream of or within calcium ion import across plasma membrane and macrophage chemotaxis. Located in plasma membrane. Is expressed in brain; midbrain hindbrain boundary; pronephric duct; and spinal cord. Orthologous to human P2RX7 (purinergic receptor P2X 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu706 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ogryzko et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb224 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ihb225 | Allele with one delins | Unknown | Unknown | CRISPR | |
| sa17772 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21329 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| xt26 | Allele with one deletion | Exon 10 | Premature Stop | CRISPR | |
| xt28 | Allele with one delins | Exon 10 | Premature Stop | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | P2X7 purinoceptor | P2X purinoreceptor | P2X purinoreceptor 7, intracellular domain | P2X purinoreceptor extracellular domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q7SZM2
|
596 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-42D10 | ZFIN Curated Data | |
| Encodes | EST | eu706 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:194725 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198984 (1) | 1858 nt | ||
| Genomic | GenBank:BX640478 (1) | 191201 nt | ||
| Polypeptide | UniProtKB:Q7SZM2 (1) | 596 aa |
- Lou, L., Yu, T., Dai, Y., Zhao, S., Feng, S., Xu, J., Wen, Z. (2022) Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression. Proceedings of the National Academy of Sciences of the United States of America. 119:e2203273119
- Whyte-Fagundes, P., Taskina, D., Safarian, N., Zoidl, C., Carlen, P.L., Donaldson, L.W., Zoidl, G.R. (2022) Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology. 5:472
- Fukui, H., Chow, R.W., Xie, J., Foo, Y.Y., Yap, C.H., Minc, N., Mochizuki, N., Vermot, J. (2021) Bioelectric signaling and the control of cardiac cell identity in response to mechanical forces. Science (New York, N.Y.). 374:351-354
- Medrano, M.P., Pisera-Fuster, A., Bernabeu, R.O., Faillace, M.P. (2020) P2X7 and A2A receptor endogenous activation protects against neuronal death caused by CoCl2 -induced photoreceptor toxicity in the zebrafish retina. The Journal of comparative neurology. 528(12):2000-2020
- Safarian, N., Whyte-Fagundes, P., Zoidl, C., Grigull, J., Zoidl, G. (2020) Visuomotor deficiency in panx1a knockout zebrafish is linked to dopaminergic signaling. Scientific Reports. 10:9538
- Zhao, X., Gong, L., Wang, C., Liu, M., Hu, N., Dai, X., Peng, C., Li, Y. (2020) Quercetin mitigates ethanol-induced hepatic steatosis in zebrafish via P2X7R-mediated PI3K/ Keap1/Nrf2 signaling pathway. Journal of ethnopharmacology. 268:113569
- de Marchi, F.O., Cruz, F.F., Menezes, F.P., Kist, L.W., Bogo, M.R., Morrone, F.B. (2019) P2X7R and PANX-1 channel relevance in a zebrafish larvae copper-induced inflammation model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 223:62-70
- Lin, X., Zhou, Q., Zhao, C., Lin, G., Xu, J., Wen, Z. (2019) An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis. Developmental Cell. 49(4):605-617.e5
- Matty, M.A., Knudsen, D.R., Walton, E.M., Beerman, R.W., Cronan, M.R., Pyle, C.J., Hernandez, R.E., Tobin, D.M. (2019) Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection. eLIFE. 8:
- Luo, J.J., Su, D.S., Xie, S.L., Liu, Y., Liu, P., Yang, X.J., Pei, D.S. (2018) Hypersensitive assessment of aryl hydrocarbon receptor transcriptional activity using a novel truncated cyp1a promoter in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(5):2814-2826
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