Gene

rad21a

ID

ZDB-GENE-030131-994

Name

RAD21 cohesin complex component a

Symbol

rad21a Nomenclature History

Previous Names

rad21
wu:fb55d02
wu:fb93f04

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Enables sequence-specific DNA binding activity. Acts upstream of or within several processes, including chordate embryonic development; enteric nervous system development; and heart development. Predicted to be located in several cellular components, including chromosome, centromeric region; nuclear matrix; and spindle pole. Predicted to be part of cohesin complex. Is expressed in several structures, including brain; digestive system; head; optic cup; and ventricular zone. Used to study Cornelia de Lange syndrome and brain cancer. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human RAD21 (RAD21 cohesin complex component).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55325 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 34 figures from 11 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rad21a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Cornelia de Lange syndrome 4	Alliance	Cornelia de Lange syndrome 4	614701
		?Mungan syndrome	611376

Associated With rad21a Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital heart disease	sd2Tg; zp5Tg + MO2-rad21a	standard conditions	Schuster et al., 2015
congenital heart disease	c262Tg + MO2-rad21a	standard conditions	Schuster et al., 2015
brain cancer	rad21a^hi2529Tg/+; hzm5Et	standard conditions	Idilli et al., 2020
Cornelia de Lange syndrome	rad21a^hi2529Tg	standard conditions	Xu et al., 2015
Cornelia de Lange syndrome	WT + MO2-rad21a	standard conditions	Xu et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006909	Rad21/Rec8-like protein, C-terminal, eukaryotic
Domain	IPR006910	Rad21/Rec8-like protein, N-terminal
Domain	IPR049589	NXP-1, middle HEAT-repeat binding domain
Family	IPR039781	Rad21/Rec8-like protein
Homologous_superfamily	IPR023093	ScpA-like, C-terminal
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	NXP-1, middle HEAT-repeat binding domain	Rad21/Rec8-like protein	Rad21/Rec8-like protein, C-terminal, eukaryotic	Rad21/Rec8-like protein, N-terminal	ScpA-like, C-terminal	Winged helix DNA-binding domain superfamily
UniProtKB:Q6TEL1 InterPro	643

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rad21a-201 (1) Ensembl	Ensembl	2,622 nt	Select Tool ZFIN BLAST
mRNA	rad21a-203 (1) Ensembl	Ensembl	1,939 nt	Select Tool ZFIN BLAST
ncRNA	ottdart00000061991 (1) Ensembl	Ensembl	709 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-rad21	polyclonal	rad21a		Rabbit			3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations