Gene
rad21a
- ID
- ZDB-GENE-030131-994
- Name
- RAD21 cohesin complex component a
- Symbol
- rad21a Nomenclature History
- Previous Names
-
- rad21
- wu:fb55d02
- wu:fb93f04
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Exhibits sequence-specific DNA binding activity. Involved in several processes, including chordate embryonic development; enteric nervous system development; and heart development. Predicted to localize to meiotic cohesin complex and nuclear cohesin complex. Used to study Cornelia de Lange syndrome. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4. Is expressed in several structures, including brain; digestive system; head; optic cup; and ventricular zone. Orthologous to human RAD21 (RAD21 cohesin complex component).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55325 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 34 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Cornelia de Lange syndrome 4 | Alliance | Cornelia de Lange syndrome 4 | 614701 |
?Mungan syndrome | 611376 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR006909 | Rad21/Rec8-like protein, C-terminal, eukaryotic |
Domain | IPR006910 | Rad21/Rec8-like protein, N-terminal |
Domain | IPR049589 | NXP-1, middle HEAT-repeat binding domain |
Family | IPR039781 | Rad21/Rec8-like protein |
Homologous_superfamily | IPR023093 | ScpA-like, C-terminal |
Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
Protein | Length | NXP-1, middle HEAT-repeat binding domain | Rad21/Rec8-like protein | Rad21/Rec8-like protein, C-terminal, eukaryotic | Rad21/Rec8-like protein, N-terminal | ScpA-like, C-terminal | Winged helix DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|
UniProtKB:Q6TEL1
|
643 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
rad21a-201
(1)
|
Havana | 2622 nt | |
mRNA |
rad21a-203
(1)
|
Ensembl | 1939 nt | |
ncRNA |
ottdart00000061991
(1)
|
Havana | 709 nt |
Interactions and Pathways
No data available
Plasmids
No data available