Gene
yap1
- ID
- ZDB-GENE-030131-9710
- Name
- Yes1 associated transcriptional regulator
- Symbol
- yap1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Involved in several processes, including dorsal/ventral axis specification; embryonic hemopoiesis; and heart formation. Acts upstream of with a positive effect on BMP signaling pathway. Acts upstream of or within several processes, including Kupffer's vesicle development; circulatory system development; and sensory system development. Located in chromatin and nucleus. Is expressed in several structures, including central nervous system; digestive system; fin; mesoderm; and tail bud. Used to study coloboma. Human ortholog(s) of this gene implicated in uveal coloboma-cleft lip and palate-intellectual disability. Orthologous to human YAP1 (Yes1 associated transcriptional regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb194 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 50 figures from 21 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns19 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | CRISPR | |
| bns22 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| fu47 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | TALEN | |
| fu48 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | TALEN | |
| la013286Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la020426Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mw48 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| mw69 | Allele with one deletion | Unknown | Unknown | TALEN | |
| ncv101 | Allele with one deletion | Exon 1 | Premature Stop | TALEN | |
| ncv117 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| uveal coloboma-cleft lip and palate-intellectual disability | Alliance | Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development | 120433 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| coloboma | yap1nl13/nl13 | standard conditions | Miesfeld et al., 2015 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | TEAD interating region 3, omega loop | WW domain | WW domain superfamily | Yes-associated protein 1 |
|---|---|---|---|---|---|
|
UniProtKB:Q1L8J7
|
442 | ||||
|
UniProtKB:A0A8M2BKX9
|
404 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-yap1 | monoclonal | IgG2a | Mouse |
|
Santa Cruz Biotechnology, Inc.
|
7 | |
| Ab1-yap1 | polyclonal | Rabbit |
|
Cell Signaling Technology, Inc.
|
17 |
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Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-3B8 | ZFIN Curated Data | |
| Encodes | EST | cb194 | Thisse et al., 2001 | |
| Encodes | EST | fc18c04 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158380 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001139480 (1) | 3940 nt | ||
| Genomic | GenBank:AL954841 (1) | 149277 nt | ||
| Polypeptide | UniProtKB:Q1L8J7 (2) | 442 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Albu, M., Affolter, E., Gentile, A., Xu, Y., Kikhi, K., Howard, S., Kuenne, C., Priya, R., Gunawan, F., Stainier, D.Y.R. (2024) Distinct mechanisms regulate ventricular and atrial chamber wall formation. Nature communications. 15:81598159
- Dong, Y., Yang, Y., Wang, H., Feng, D., Nist, E., Yapundich, N., Spurlock, B., Craft, M., Qian, L., Liu, J. (2024) Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells. Science advances. 10:eadk4694eadk4694
- Lu, C., Hyde, D.R. (2024) Cytokines IL-1β and IL-10 are required for Müller glia proliferation following light damage in the adult zebrafish retina. Frontiers in cell and developmental biology. 12:14063301406330
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Zhang, P., Cao, J., Liang, X., Su, Z., Zhang, B., Wang, Z., Xie, J., Chen, G., Chen, X., Zhang, J., Feng, Y., Xu, Q., Song, J., Hong, A., Chen, X., Zhang, Y. (2024) Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis. Acta biochimica et biophysica Sinica. 56(4):621-633
- Lee, S.H., So, J., Shin, D. (2023) Hepatocyte-to-cholangiocyte conversion occurs through transdifferentiation independently of proliferation in zebrafish. Hepatology (Baltimore, Md.). 77(4):1198-1210
- Li, H., Luo, Q., Cai, S., Tie, R., Meng, Y., Shan, W., Xu, Y., Zeng, X., Qian, P., Huang, H. (2023) Glia maturation factor-γ is required for initiation and maintenance of hematopoietic stem and progenitor cells. Stem Cell Research & Therapy. 14:117117
- Ye, F., Niu, X., Liang, F., Dai, Y., Liang, J., Li, J., Wu, X., Zheng, H., Qi, T., Sheng, W. (2023) RNF213 loss-of-function promotes pathological angiogenesis in moyamoya disease via the Hippo pathway. Brain : a journal of neurology. 146(11):4674-4689
- Zhao, Y., Wang, H., He, T., Ma, B., Chen, G., Tzeng, C. (2023) Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals. Journal of cell communication and signaling. 17(4):1335-1354
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