Gene
ftcd
- ID
- ZDB-GENE-030131-9643
- Name
- formimidoyltransferase cyclodeaminase
- Symbol
- ftcd Nomenclature History
- Previous Names
-
- wu:fp37b11
- zgc:63647
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have folic acid binding activity and transferase activity. Predicted to be involved in cellular metabolic process. Localizes to Golgi apparatus. Human ortholog(s) of this gene implicated in glutamate formiminotransferase deficiency. Is expressed in liver; pronephric duct; and yolk syncytial layer. Orthologous to human FTCD (formimidoyltransferase cyclodeaminase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148782 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| glutamate formiminotransferase deficiency | Alliance | Glutamate formiminotransferase deficiency | 229100 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004227 | Formiminotransferase catalytic domain |
| Domain | IPR007044 | Cyclodeaminase/cyclohydrolase |
| Domain | IPR012886 | Formiminotransferase, N-terminal subdomain |
| Domain | IPR013802 | Formiminotransferase, C-terminal subdomain |
| Family | IPR051623 | Formiminotransferase-cyclodeaminase |
| Homologous_superfamily | IPR022384 | Formiminotransferase catalytic domain superfamily |
| Homologous_superfamily | IPR036178 | Formimidoyltransferase-cyclodeaminase-like superfamily |
| Homologous_superfamily | IPR037064 | Formiminotransferase, N-terminal subdomain superfamily |
| Homologous_superfamily | IPR037070 | Formiminotransferase, C-terminal subdomain superfamily |
Domain Details Per Protein
| Protein | Length | Cyclodeaminase/cyclohydrolase | Formimidoyltransferase-cyclodeaminase-like superfamily | Formiminotransferase catalytic domain | Formiminotransferase catalytic domain superfamily | Formiminotransferase, C-terminal subdomain | Formiminotransferase, C-terminal subdomain superfamily | Formiminotransferase-cyclodeaminase | Formiminotransferase, N-terminal subdomain | Formiminotransferase, N-terminal subdomain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1PIL2
|
540 |
Interactions and Pathways
No data available
Plasmids
No data available