Gene
ftcd
- ID
- ZDB-GENE-030131-9643
- Name
- formimidoyltransferase cyclodeaminase
- Symbol
- ftcd Nomenclature History
- Previous Names
-
- wu:fp37b11
- zgc:63647
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable folic acid binding activity; formimidoyltetrahydrofolate cyclodeaminase activity; and transferase activity. Predicted to be involved in histidine catabolic process to glutamate and formamide; histidine catabolic process to glutamate and formate; and tetrahydrofolate interconversion. Predicted to act upstream of or within histidine metabolic process. Located in Golgi apparatus. Is expressed in liver; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in glutamate formiminotransferase deficiency. Orthologous to human FTCD (formimidoyltransferase cyclodeaminase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148782 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cq107 | Allele with one point mutation | Exon 6 | Unknown | ENU | |
| cq108 | Allele with one deletion | Exon 6 | Unknown | CRISPR | |
| cq108n | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la022157Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9153 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14646 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24106 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| glutamate formiminotransferase deficiency | Alliance | Glutamate formiminotransferase deficiency | 229100 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004227 | Formiminotransferase catalytic domain |
| Domain | IPR007044 | Cyclodeaminase/cyclohydrolase |
| Domain | IPR012886 | Formiminotransferase, N-terminal subdomain |
| Domain | IPR013802 | Formiminotransferase, C-terminal subdomain |
| Family | IPR051623 | Formiminotransferase-cyclodeaminase |
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Domain Details Per Protein
| Protein | Length | Cyclodeaminase/cyclohydrolase | Formimidoyltransferase-cyclodeaminase-like superfamily | Formiminotransferase catalytic domain | Formiminotransferase catalytic domain superfamily | Formiminotransferase, C-terminal subdomain | Formiminotransferase, C-terminal subdomain superfamily | Formiminotransferase-cyclodeaminase | Formiminotransferase, N-terminal subdomain | Formiminotransferase, N-terminal subdomain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1PIL2
|
540 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(fabp10a:ftcd-2A-DsRed) |
| 1 | Zhang et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-84A8 | ZFIN Curated Data | |
| Encodes | EST | fp37b11 | ||
| Encodes | EST | IMAGE:7148782 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:63647 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201077 (1) | 1707 nt | ||
| Genomic | GenBank:BX548072 (1) | 188936 nt | ||
| Polypeptide | UniProtKB:A0A8M1PIL2 (1) | 540 aa |
- Zhang, W., Wu, C., Ni, R., Yang, Q., Luo, L., He, J. (2021) Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. PLoS Genetics. 17:e1009980
- Zhang, C., Zhang, Q., Wang, J., Tian, J., Song, Y., Xie, H., Chang, M., Nie, P., Gao, Q., Zou, J. (2019) Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Fish & shellfish immunology. 94:685-696
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Yabu, T., Imamura, S., Yamashita, M., and Okazaki, T. (2008) Identification of Mg2+-dependent neutral sphingomyelinase 1 as a mediator of heat stress-induced ceramide generation and apoptosis. The Journal of biological chemistry. 283(44):29971-29982
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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