Gene

chek2

ID

ZDB-GENE-030131-8942

Name

checkpoint kinase 2

Symbol

chek2 Nomenclature History

Previous Names

chk2 (1)
fa66f08
wu:fa66f08
zgc:55865

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Involved in cellular response to DNA damage stimulus. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Is expressed in eye; head; optic tectum; and proliferative region. Orthologous to human CHEK2 (checkpoint kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With chek2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Li-Fraumeni syndrome 2	Alliance	Tumor predisposition syndrome 4, breast/prostate/colorectal	609265
osteosarcoma	Alliance	Osteosarcoma, somatic	259500
prostate cancer	Alliance	Prostate cancer, somatic	176807

Associated With chek2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Domain	IPR000253	Forkhead-associated (FHA) domain
Domain	IPR000719	Protein kinase domain
Homologous_superfamily	IPR008984	SMAD/FHA domain superfamily
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily