Gene
ddx46
- ID
- ZDB-GENE-030131-667
- Name
- DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
- Symbol
- ddx46 Nomenclature History
- Previous Names
-
- fb39a03
- fj67d06
- wu:fb39a03 (1)
- wu:fj67d06
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Acts upstream of or within several processes, including digestive system development; liver morphogenesis; and positive regulation of cell differentiation. Predicted to be located in Cajal body and nuclear speck. Predicted to be active in nucleus. Is expressed in brain; digestive system; head; hematopoietic system; and pectoral fin bud. Orthologous to human DDX46 (DEAD-box helicase 46).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ha4 | Allele with one point mutation | Unknown | Missense | ENU | |
| hi2137Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la014107Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa15606 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37388 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37389 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 6 of 6
Show
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000629 | ATP-dependent RNA helicase DEAD-box, conserved site |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR011545 | DEAD/DEAH box helicase domain |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR014014 | RNA helicase, DEAD-box type, Q motif |
1 - 5 of 7 Show all
Domain Details Per Protein
| Protein | Length | ATP-dependent RNA helicase DEAD-box, conserved site | DEAD box RNA helicase | DEAD/DEAH box helicase domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | RNA helicase, DEAD-box type, Q motif |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q4TVV3
|
1018 | |||||||
|
UniProtKB:A0A8M3AX96
|
1035 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-25G7 | ZFIN Curated Data | |
| Encodes | EST | fb39a03 | ||
| Encodes | EST | fj67d06 |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001024817 (1) | 3247 nt | ||
| Genomic | GenBank:CU302316 (1) | 166312 nt | ||
| Polypeptide | UniProtKB:A0A8M3AX96 (1) | 1035 aa |
- Huang, G., Zhang, F., Ye, Q., Wang, H. (2016) The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish. Autophagy. 12(8):1292-309
- Iwanami, N. (2014) Zebrafish as a model for understanding the evolution of the vertebrate immune system and human primary immunodeficiency. Experimental hematology. 42(8):697-706
- Hirabayashi, R., Hozumi, S., Higashijima, S.I., and Kikuchi, Y. (2013) Ddx46 Is Required for Multi-Lineage Differentiation of Hematopoietic Stem Cells in Zebrafish. Stem cells and development. 22(18):2532-42
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Hozumi, S., Hirabayashi, R., Yoshizawa, A., Ogata, M., Ishitani, T., Tsutsumi, M., Kuroiwa, A., Itoh, M., and Kikuchi, Y. (2012) DEAD-Box Protein Ddx46 Is Required for the Development of the Digestive Organs and Brain in Zebrafish. PLoS One. 7(3):e33675
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
1 - 6 of 6
Show