Gene
boc
- ID
- ZDB-GENE-030131-6560
- Name
- BOC cell adhesion associated, oncogene regulated
- Symbol
- boc Nomenclature History
- Previous Names
-
- fa16d03
- uml
- umleitung (1)
- wu:fa16d03
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables identical protein binding activity. Acts upstream of or within regulation of smoothened signaling pathway and retinal ganglion cell axon guidance. Predicted to be located in plasma membrane. Predicted to be active in axon. Is expressed in several structures, including anterior neural keel; nervous system; neural plate; neural rod; and neural tube. Orthologous to human BOC (BOC cell adhesion associated, oncogene regulated).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu441 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| co24 | unknown | Unknown | Premature Stop | ENU | |
| la028610Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa37879 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37880 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44130 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ty54z | Allele with one point mutation | Exon 5 | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8UVD6
|
1032 |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-196K8 | ZFIN Curated Data | |
| Contains | SNP | rs3729328 | ZFIN Curated Data | |
| Encodes | EST | eu441 | Thisse et al., 2005 | |
| Encodes | EST | fa16d03 | ||
| Encodes | cDNA | cssl:d104 | Bushell et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001005393 (1) | 3373 nt | ||
| Genomic | GenBank:CU915780 (2) | 112412 nt | ||
| Polypeptide | UniProtKB:Q8UVD6 (1) | 1032 aa |
- Lencer, E., Rains, A., Binne, E., Prekeris, R., Artinger, K. (2023) Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish. Development (Cambridge, England). 150(14):
- Kearns, C.A., Walker, M., Ravanelli, A.M., Scott, K., Arzbecker, M.R., Appel, B. (2021) Zebrafish spinal cord oligodendrocyte formation requires boc function. Genetics. 218(4):
- Scott, K., O'Rourke, R., Gillen, A., Appel, B. (2020) Prdm8 regulates pMN progenitor specification for motor neuron and oligodendrocyte fates by modulating Shh signaling response. Development (Cambridge, England). 147(16):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Cardozo, M.J., Sánchez-Arrones, L., Sandonis, A., Sánchez-Camacho, C., Gestri, G., Wilson, S.W., Guerrero, I., Bovolenta, P. (2014) Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle. Nature communications. 5:4272
- John, J.A., Scott, S., Chua, K.Y., Claxton, C., and Key, B. (2013) Growth cone dynamics in the zebrafish embryonic forebrain is regulated by Brother of CDO. Neuroscience letters. 545:11-6
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Bergeron, S.A., Tyurina, O.V., Miller, E., Bagas, A., and Karlstrom, R.O. (2011) Brother of cdo (umleitung) is cell-autonomously required for Hedgehog-mediated ventral CNS patterning in the zebrafish. Development (Cambridge, England). 138(1):75-85
- Charoensawan, V., Adryan, B., Martin, S., Söllner, C., Thisse, B., Thisse, C., Wright, G.J., and Teichmann, S.A. (2010) The Impact of Gene Expression Regulation on Evolution of Extracellular Signaling Pathways. Molecular & cellular proteomics : MCP. 9(12):2666-2677
- Martin, S., Söllner, C., Charoensawan, V., Adryan, B., Thisse, B., Thisse, C., Teichmann, S.A., and Wright, G.J. (2010) Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Molecular & cellular proteomics : MCP. 9(12):2654-2665
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