Gene

cbx5

ID

ZDB-GENE-030131-5553

Name

chromobox homolog 5 (HP1 alpha homolog, Drosophila)

Symbol

cbx5 Nomenclature History

Previous Names

fc63e02
id:ibd2026
wu:fc63e02
wu:fe47g12
wu:fi03h05
zgc:158601

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable chromatin binding activity and methylated histone binding activity. Predicted to be involved in chromatin organization and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in pericentric heterochromatin. Is expressed in somite. Orthologous to human CBX5 (chromobox 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6909494 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Calvird et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cbx5 Human Ortholog

No data available

Associated With cbx5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023779	Chromo domain, conserved site
Domain	IPR000953	Chromo/chromo shadow domain
Domain	IPR008251	Chromo shadow domain
Domain	IPR017984	Chromo domain subgroup
Domain	IPR023780	Chromo domain
Family	IPR051219	Heterochromatin-associated chromo domain-containing protein
Homologous_superfamily	IPR016197	Chromo-like domain superfamily

Domain Details Per Protein

Protein	Length	Chromo/chromo shadow domain	Chromo domain	Chromo domain, conserved site	Chromo domain subgroup	Chromo-like domain superfamily	Chromo shadow domain	Heterochromatin-associated chromo domain-containing protein
UniProtKB:A1L223 InterPro	204

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cbx5-201 (1) Ensembl	Ensembl	1,867 nt	Select Tool ZFIN BLAST
mRNA	cbx5-202 (1) Ensembl	Ensembl	775 nt	Select Tool ZFIN BLAST
mRNA	cbx5-203 (1) Ensembl	Ensembl	1,028 nt	Select Tool ZFIN BLAST
mRNA	cbx5-204 (1) Ensembl	Ensembl	1,264 nt	Select Tool ZFIN BLAST
mRNA	cbx5-205 (1) Ensembl	Ensembl	2,989 nt	Select Tool ZFIN BLAST
mRNA	cbx5-206 (1) Ensembl	Ensembl	759 nt	Select Tool ZFIN BLAST
mRNA	cbx5-207 (1) Ensembl	Ensembl	818 nt	Select Tool ZFIN BLAST
mRNA	cbx5-208 (1) Ensembl	Ensembl	633 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations