Gene
apol1
- ID
- ZDB-GENE-030131-3217
- Name
- apolipoprotein L, 1
- Symbol
- apol1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have lipid binding activity. Involved in glomerular filtration; glomerular visceral epithelial cell development; and pronephric glomerulus morphogenesis. Predicted to localize to extracellular region and integral component of membrane. Used to study kidney disease. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis. Is expressed in brain; heart; integument; liver; and pleuroperitoneal region. Orthologous to human APOL1 (apolipoprotein L1); APOL3 (apolipoprotein L3); and APOL5 (apolipoprotein L5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Glomerulosclerosis, focal segmental, 4, susceptibility to} | 612551 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| kidney disease | AB/EKW + MO2-apol1 | standard conditions | Anderson et al., 2015 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR008405 | Apolipoprotein L |
Domain Details Per Protein
| Protein | Length | Apolipoprotein L |
|---|---|---|
|
UniProtKB:A0A8M2BIK6
|
440 | |
|
UniProtKB:A0A8M2BIK2
|
464 | |
|
UniProtKB:A0A8M2BJ26
|
465 | |
|
UniProtKB:Q7T131
|
326 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available