Gene
vapb
- ID
- ZDB-GENE-030131-2348
- Name
- VAMP (vesicle-associated membrane protein)-associated protein B and C
- Symbol
- vapb Nomenclature History
- Previous Names
-
- fc05d09
- wu:fa96d05
- wu:fc05d09
- zgc:66045 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have FFAT motif binding activity. Involved in swimming behavior. Predicted to localize to endoplasmic reticulum membrane and plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Is expressed in atrium; cardiac ventricle; and heart. Orthologous to human VAPB (VAMP associated protein B and C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
amyotrophic lateral sclerosis type 8 | Alliance | Amyotrophic lateral sclerosis 8 | 608627 |
autosomal dominant adult-onset proximal spinal muscular atrophy | Alliance | Spinal muscular atrophy, late-onset, Finkel type | 182980 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Immunoglobulin-like fold | Major sperm protein (MSP) domain | PapD-like superfamily | Vesicle-associated membrane-protein-associated protein |
---|---|---|---|---|---|
UniProtKB:A0A8M9PZG9
|
242 | ||||
UniProtKB:Q6P2B0
|
243 |
Interactions and Pathways
No data available
Plasmids
No data available