Gene
vapb
- ID
- ZDB-GENE-030131-2348
- Name
- VAMP (vesicle-associated membrane protein)-associated protein B and C
- Symbol
- vapb Nomenclature History
- Previous Names
-
- fc05d09
- wu:fa96d05
- wu:fc05d09
- zgc:66045 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable FFAT motif binding activity. Acts upstream of or within regulation of heart contraction and swimming behavior. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Is expressed in atrium; cardiac ventricle; and heart. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPB (VAMP associated protein B and C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 8 | Alliance | Amyotrophic lateral sclerosis 8 | 608627 |
| autosomal dominant adult-onset proximal spinal muscular atrophy | Alliance | Spinal muscular atrophy, late-onset, Finkel type | 182980 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Immunoglobulin-like fold | Major sperm protein (MSP) domain | PapD-like superfamily | Vesicle-associated membrane-protein-associated protein |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PZG9
|
242 | ||||
|
UniProtKB:Q6P2B0
|
243 |
Interactions and Pathways
No data available
Plasmids
No data available