Gene
ewsr1a
- ID
- ZDB-GENE-030131-2317
- Name
- EWS RNA-binding protein 1a
- Symbol
- ewsr1a Nomenclature History
- Previous Names
-
- fc04c01
- wu:fc04c01
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Exhibits chromatin binding activity. Involved in several processes, including central nervous system neuron development; mitotic spindle midzone assembly; and regulation of chondrocyte hypertrophy. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Ewing sarcoma | Alliance | Ewing sarcoma | 612219 |
Ewing sarcoma | Alliance | Neuroepithelioma | 612219 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000504 | RNA recognition motif domain |
Domain | IPR001876 | Zinc finger, RanBP2-type |
Domain | IPR034869 | EWS, RNA recognition motif |
Family | IPR034870 | TAF15/EWS/TLS family |
Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
Homologous_superfamily | IPR036443 | Zinc finger, RanBP2-type superfamily |
Domain Details Per Protein
Protein | Length | EWS, RNA recognition motif | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain | TAF15/EWS/TLS family | Zinc finger, RanBP2-type | Zinc finger, RanBP2-type superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q6NUX1
|
624 | |||||||
UniProtKB:A0A0B4J1A5
|
626 | |||||||
UniProtKB:A0A8M9QKJ4
|
319 | |||||||
UniProtKB:A0A8M9QBU8
|
597 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
ewsr1a-201
(1)
|
Ensembl | 2,456 nt | ||
mRNA |
ewsr1a-203
(1)
|
Ensembl | 986 nt | ||
ncRNA |
ewsr1a-003
(1)
|
Ensembl | 497 nt | ||
ncRNA |
ewsr1a-004
(1)
|
Ensembl | 1,251 nt |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-ewsr1a | polyclonal | Rabbit |
|
1 |
Plasmids
No data available