Gene

ewsr1a

ID
ZDB-GENE-030131-2317
Name
EWS RNA-binding protein 1a
Symbol
ewsr1a Nomenclature History
Previous Names
  • fc04c01
  • wu:fc04c01
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Exhibits chromatin binding activity. Involved in several processes, including central nervous system neuron development; mitotic spindle midzone assembly; and regulation of chondrocyte hypertrophy. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ewsr1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Ewing sarcoma Alliance Ewing sarcoma 612219
Ewing sarcoma Alliance Neuroepithelioma 612219
Associated With ewsr1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000504 RNA recognition motif domain
Domain IPR001876 Zinc finger, RanBP2-type
Domain IPR034869 EWS, RNA recognition motif
Family IPR034870 TAF15/EWS/TLS family
Homologous_superfamily IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily IPR035979 RNA-binding domain superfamily
Homologous_superfamily IPR036443 Zinc finger, RanBP2-type superfamily
Domain Details Per Protein
Protein Length EWS, RNA recognition motif Nucleotide-binding alpha-beta plait domain superfamily RNA-binding domain superfamily RNA recognition motif domain TAF15/EWS/TLS family Zinc finger, RanBP2-type Zinc finger, RanBP2-type superfamily
UniProtKB:Q6NUX1 624
UniProtKB:A0A0B4J1A5 626
UniProtKB:A0A8M9QKJ4 319
UniProtKB:A0A8M9QBU8 597
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ewsr1a-201 (1) Ensembl 2,456 nt
mRNA ewsr1a-203 (1) Ensembl 986 nt
ncRNA ewsr1a-003 (1) Ensembl 497 nt
ncRNA ewsr1a-004 (1) Ensembl 1,251 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ewsr1a polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations