Gene
flrt3
- ID
- ZDB-GENE-030131-1988
- Name
- fibronectin leucine rich transmembrane 3
- Symbol
- flrt3 Nomenclature History
- Previous Names
-
- fb93g11
- si:dkeyp-24h12.1
- wu:fb75d02
- wu:fb93g11 (1)
- wu:fc10a05
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have fibroblast growth factor receptor binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway and positive regulation of synapse assembly. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 21 with or without anosmia. Is expressed in several structures, including mesoderm; midbrain hindbrain boundary neural keel; nervous system; optic primordium; and optic vesicle. Orthologous to human FLRT3 (fibronectin leucine rich transmembrane protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu497 (25 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 21 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 21 with anosmia | 615271 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000372 | Leucine-rich repeat N-terminal domain |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR003961 | Fibronectin type III |
| Family | IPR050333 | Small Leucine-Rich Proteoglycans |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
Domain Details Per Protein
| Protein | Length | Cysteine-rich flanking region, C-terminal | Fibronectin type III | Immunoglobulin-like fold | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype | Small Leucine-Rich Proteoglycans |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B8A507
|
649 |
Interactions and Pathways
No data available
Plasmids