Gene
klf6a
- ID
- ZDB-GENE-021115-9
- Name
- Kruppel like factor 6a
- Symbol
- klf6a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; optic nerve formation; and regulation of hematopoietic stem cell proliferation. Localizes to chromatin. Human ortholog(s) of this gene implicated in prostate cancer. Is expressed in several structures, including cardiovascular system; digestive system; intermediate cell mass of mesoderm; nervous system; and pleuroperitoneal region. Orthologous to human KLF6 (Kruppel like factor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb538 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| prostate cancer | Alliance | Prostate cancer, somatic | 176807 |
| stomach cancer | Alliance | Gastric cancer, somatic | 613659 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|
|
UniProtKB:F1R7F0
|
283 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-klf6a | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids
No data available