Gene
plod3
- ID
- ZDB-GENE-021031-4
- Name
- procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
- Symbol
- plod3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable procollagen glucosyltransferase activity and procollagen-lysine 5-dioxygenase activity. Acts upstream of or within motor neuron axon guidance and neural crest cell migration. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of collagen trimer. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including axis; eye; mesoderm; pectoral fin; and splanchnocranium. Orthologous to human PLOD3 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb479 (16 images)
- cb816 (11 images)
- IMAGE:6912725 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 22 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| BCARD syndrome (lysyl hydroxylase 3 deficiency) | 612394 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001006 | Procollagen-lysine 5-dioxygenase, conserved site |
| Domain | IPR005123 | Oxoglutarate/iron-dependent dioxygenase domain |
| Domain | IPR006620 | Prolyl 4-hydroxylase, alpha subunit |
| Domain | IPR044861 | Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain |
| Family | IPR050757 | Collagen-modifying Glycosyltransferase 25 |
| Homologous_superfamily | IPR029044 | Nucleotide-diphospho-sugar transferases |
Domain Details Per Protein
| Protein | Length | Collagen-modifying Glycosyltransferase 25 | Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain | Nucleotide-diphospho-sugar transferases | Oxoglutarate/iron-dependent dioxygenase domain | Procollagen-lysine 5-dioxygenase, conserved site | Prolyl 4-hydroxylase, alpha subunit |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A3KNH4
|
730 | ||||||
|
UniProtKB:A0A8M2B9A3
|
686 |
Interactions and Pathways
No data available
Plasmids
No data available