Gene
vangl2
- ID
- ZDB-GENE-020507-3
- Name
- VANGL planar cell polarity protein 2
- Symbol
- vangl2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Involved in several processes, including chordate embryonic development; convergent extension involved in gastrulation; and regulation of Wnt signaling pathway. Acts upstream of or within several processes, including cytoskeleton organization; embryonic morphogenesis; and generation of neurons. Located in plasma membrane. Is expressed in central nervous system; liver; pharyngeal arch; and sensory system. Used to study ciliopathy. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 105 figures from 54 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hsc170Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| la026205Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026206Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| m144 | unknown | Unknown | Unknown | ENU | |
| m209 | Allele with one point mutation | Intron 7 | Frameshift, Premature Stop | ENU | |
| m747 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| m778 | unknown | Unknown | Unknown | ENU | |
| rw75 | unknown | Unknown | Unknown | not specified | |
| sa12076 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18862 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neural tube defects | 182940 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| ciliopathy | WT + MO1-vangl2 | standard conditions | Leightner et al., 2013 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR009539 | Vang-like protein |
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Domain Details Per Protein
| Protein | Length | Vang-like protein |
|---|---|---|
|
UniProtKB:Q8UVJ6
|
526 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
vangl2-201
(1)
|
Ensembl | 5,862 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-vangl2 | polyclonal | IgG | Goat |
|
Santa Cruz Biotechnology, Inc.
|
2 |
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Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | cDNA | MGC:76845 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_153674 (1) | 2188 nt | ||
| Genomic | GenBank:CABZ01078578 (1) | 71077 nt | ||
| Polypeptide | UniProtKB:Q8UVJ6 (1) | 526 aa |
- Feng, X., Ye, Y., Zhang, J., Zhang, Y., Zhao, S., Mak, J.C.W., Otomo, N., Zhao, Z., Niu, Y., Yonezawa, Y., Li, G., Lin, M., Li, X., Cheung, P.W.H., Xu, K., Takeda, K., Wang, S., Xie, J., Kotani, T., Choi, V.N.T., Song, Y.Q., Yang, Y., Luk, K.D.K., Lee, K.S., Li, Z., Li, P.S., Leung, C.Y.H., Lin, X., Wang, X., Qiu, G., DISCO (Deciphering disorders Involving Scoliosis and COmorbidities) study group, Watanabe, K., Japanese Early Onset Scoliosis Research Group, Wu, Z., Posey, J.E., Ikegawa, S., Lupski, J.R., Cheung, J.P.Y., Zhang, T.J., Gao, B., Wu, N. (2024) Core planar cell polarity genes VANGL1 and VANGL2 in predisposition to congenital vertebral malformations. Proceedings of the National Academy of Sciences of the United States of America. 121:e2310283121e2310283121
- Čapek, D., Safroshkin, M., Morales-Navarrete, H., Toulany, N., Arutyunov, G., Kurzbach, A., Bihler, J., Hagauer, J., Kick, S., Jones, F., Jordan, B., Müller, P. (2023) EmbryoNet: using deep learning to link embryonic phenotypes to signaling pathways. Nature Methods. 20(6):815-823
- Derrick, C.J., Szenker-Ravi, E., Santos-Ledo, A., Alqahtani, A., Yusof, A., Eley, L., Coleman, A.H.L., Tohari, S., Ng, A.Y., Venkatesh, B., Alharby, E., Mansard, L., Bonnet-Dupeyron, M.N., Roux, A.F., Vaché, C., Roume, J., Bouvagnet, P., Almontashiri, N.A.M., Henderson, D.J., Reversade, B., Chaudhry, B. (2023) Functional analysis of germline VANGL2 variants using rescue assays of vangl2 knockout zebrafish. Human molecular genetics. 33(2):150-169
- Atienzar-Aroca, R., Ferre-Fernández, J.J., Tevar, A., Bonet-Fernández, J.M., Cabañero, M.J., Ruiz-Pastor, M.J., Cuenca, N., Aroca-Aguilar, J.D., Escribano, J. (2022) Transgenic Overexpression of Myocilin Leads to Variable Ocular Anterior Segment and Retinal Alterations Associated with Extracellular Matrix Abnormalities in Adult Zebrafish. International Journal of Molecular Sciences. 23(17)
- Baniel, A., Ziv, L., Ben-Moshe, Z., Sarig, O., Mohamad, J., Peled, A., Rechavi, G., Gothilf, Y., Sprecher, E. (2022) Cutaneous and Developmental Effects of CARD14 Overexpression in Zebrafish. Biomedicines. 10(12):
- Jussila, M., Boswell, C.W., Griffiths, N.W., Pumputis, P.G., Ciruna, B. (2022) Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2. Nature communications. 13:5598
- Balaraju, A.K., Hu, B., Rodriguez, J.J., Murry, M., Lin, F. (2021) Glypican 4 regulates planar cell polarity of endoderm cells by controlling the localization of Cadherin 2. Development (Cambridge, England). 148(14):
- Brunt, L., Greicius, G., Rogers, S., Evans, B.D., Virshup, D.M., Wedgwood, K.C.A., Scholpp, S. (2021) Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling. Nature communications. 12:2058
- Donati, A., Anselme, I., Schneider-Maunoury, S., Vesque, C. (2021) Planar polarization of cilia in the zebrafish floor-plate involves Par3-mediated posterior localization of highly motile basal bodies. Development (Cambridge, England). 148(13):
- Feng, D., Wang, J., Yang, W., Li, J., Lin, X., Zha, F., Wang, X., Ma, L., Choi, N.T., Mii, Y., Takada, S., Huen, M.S.Y., Guo, Y., Zhang, L., Gao, B. (2021) Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Vangl ubiquitination and endoplasmic reticulum-associated degradation. Science advances. 7(20):
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