Gene
dmbx1a
- ID
- ZDB-GENE-020117-1
- Name
- diencephalon/mesencephalon homeobox 1a
- Symbol
- dmbx1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in brain development; eye development; and negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including midbrain development; regulation of neural retina development; and retina development in camera-type eye. Predicted to be located in nucleus. Is expressed in several structures, including anterior neural keel; anterior neural rod; immature eye; nervous system; and presumptive diencephalon. Orthologous to human DMBX1 (diencephalon/mesencephalon homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Wong et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-dmbx1a | N/A | (3) |
| MO2-dmbx1a | N/A | Kawahara et al., 2002 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Diencephalon/mesencephalon homeobox | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain |
|---|---|---|---|---|---|---|
|
UniProtKB:A4IG24
|
383 | |||||
|
UniProtKB:Q8JI10
|
388 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dmbx1a-201
(1)
|
Ensembl | 2,731 nt | ||
| mRNA |
dmbx1a-202
(1)
|
Ensembl | 2,663 nt | ||
| mRNA |
dmbx1a-203
(1)
|
Ensembl | 4,226 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-222E2 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162116 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_152977 (1) | 1408 nt | ||
| Genomic | GenBank:CU463027 (2) | 41379 nt | ||
| Polypeptide | UniProtKB:Q8JI10 (1) | 388 aa |
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Soto, X., Burton, J., Manning, C.S., Minchington, T., Lea, R., Lee, J., Kursawe, J., Rattray, M., Papalopulu, N. (2022) Sequential and additive expression of miR-9 precursors control timing of neurogenesis. Development (Cambridge, England). 149(19):
- Fittipaldi, R., Floris, P., Proserpio, V., Cotelli, F., Beltrame, M., Caretti, G. (2021) The Lysine Methylase SMYD3 Modulates Mesendodermal Commitment during Development. Cells. 10(5):
- Green, D.G., Whitener, A.E., Mohanty, S., Mistretta, B., Gunaratne, P., Yeh, A.T., Lekven, A.C. (2020) Wnt signaling regulates neural plate patterning in distinct temporal phases with dynamic transcriptional outputs. Developmental Biology. 462(2):152-164
- Martik, M.L., Gandhi, S., Uy, B.R., Gillis, J.A., Green, S.A., Simoes-Costa, M., Bronner, M.E. (2019) Evolution of the new head by gradual acquisition of neural crest regulatory circuits. Nature. 574(7780):675-678
- Yanagi, K., Sone, R., Ohga, R., Kawahara, A. (2019) Involvement of the centrosomal protein 55 (cep55) gene in zebrafish head formation. Genes to cells : devoted to molecular & cellular mechanisms. 24(10):642-649
- Albuixech-Crespo, B., López-Blanch, L., Burguera, D., Maeso, I., Sánchez-Arrones, L., Moreno-Bravo, J.A., Somorjai, I., Pascual-Anaya, J., Puelles, E., Bovolenta, P., Garcia-Fernàndez, J., Puelles, L., Irimia, M., Ferran, J.L. (2017) Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. PLoS Biology. 15:e2001573
- Ott, E., Wendik, B., Srivastava, M., Pacho, F., Töchterle, S., Salvenmoser, W., Meyer, D. (2016) Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm. Developmental Biology. 411(1):101-14
- Ben-Omran, T., Fahiminiya, S., Sorfazlian, N., Almuriekhi, M., Nawaz, Z., Nadaf, J., Abu Khadija, K., Zaineddin, S., Kamel, H., Majewski, J., Tropepe, V. (2015) Nonsense mutation in the WDR73 gene is associated with Galloway-Mowat syndrome. Journal of Medical Genetics. 52(6):381-90
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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