Gene
apoea
- ID
- ZDB-GENE-010724-18
- Name
- apolipoprotein Ea
- Symbol
- apoea Nomenclature History
- Previous Names
-
- ApoE-1 (1)
- im:7036787
- wu:fb69a05
- zgc:110064
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable lipid binding activity. Predicted to be involved in several processes, including cholesterol catabolic process; lipoprotein catabolic process; and positive regulation of nitric-oxide synthase activity. Predicted to act upstream of or within lipid transport and lipoprotein metabolic process. Predicted to be located in extracellular region. Predicted to be part of intermediate-density lipoprotein particle. Is expressed in brain; female organism; liver; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110064 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Hwang et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 1 | Alliance | {?Macular degeneration, age-related} | 603075 |
| Alzheimer's disease 2 | Alliance | Alzheimer disease 2 | 104310 |
| Alzheimer's disease 3 | Alliance | {?Alzheimer disease, protection against, due to APOE3-Christchurch} | 607822 |
| hyperlipoproteinemia type III | Alliance | Hyperlipoproteinemia, type III | 617347 |
| hyperlipoproteinemia type III | Alliance | {Coronary artery disease, severe, susceptibility to} | 617347 |
| sea-blue histiocytosis | Alliance | Sea-blue histiocyte disease | 269600 |
| Lipoprotein glomerulopathy | 611771 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Apolipoprotein A1/A4/E | Apolipoprotein A/E |
|---|---|---|---|
|
UniProtKB:Q503V2
|
269 |
Interactions and Pathways
No data available
Plasmids