Gene

apoea

ID
ZDB-GENE-010724-18
Name
apolipoprotein Ea
Symbol
apoea Nomenclature History
Previous Names
  • ApoE-1 (1)
  • im:7036787
  • wu:fb69a05
  • zgc:110064
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable lipid binding activity. Predicted to be involved in several processes, including cholesterol catabolic process; lipoprotein catabolic process; and positive regulation of nitric-oxide synthase activity. Predicted to act upstream of or within lipid transport and lipoprotein metabolic process. Predicted to be located in extracellular region. Predicted to be part of intermediate-density lipoprotein particle. Is expressed in brain; female organism; liver; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Hwang et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa36796Allele with one point mutationUnknownPremature StopENU
1 - 1 of 1
Show
Sequence Targeting Reagents
Human Disease
Associated With apoea Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
age related macular degeneration 1 Alliance {?Macular degeneration, age-related} 603075
Alzheimer's disease 2 Alliance Alzheimer disease 2 104310
Alzheimer's disease 3 Alliance {?Alzheimer disease, protection against, due to APOE3-Christchurch} 607822
hyperlipoproteinemia type III Alliance Hyperlipoproteinemia, type III 617347
hyperlipoproteinemia type III Alliance {Coronary artery disease, severe, susceptibility to} 617347
1 - 5 of 7 Show all
Associated With apoea Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000074 Apolipoprotein A/E
Family IPR050163 Apolipoprotein A1/A4/E
1 - 2 of 2
Domain Details Per Protein
Protein Length Apolipoprotein A1/A4/E Apolipoprotein A/E
UniProtKB:Q503V2 269
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 19
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA apoea-201 (1) Ensembl 781 nt
mRNA apoea-202 (1) Ensembl 1,065 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-347E22ZFIN Curated Data
ContainsSNPrs3728965
    ZFIN Curated Data
    ContainsSNPrs3728966
      ZFIN Curated Data
      ContainsSNPrs3728967
        ZFIN Curated Data
        ContainsSNPrs3728968
          ZFIN Curated Data
          EncodesESTfb69a05Rajarao et al., 2001
          EncodesESTIMAGE:7036787
          EncodescDNAMGC:110064ZFIN Curated Data
          1 - 8 of 8
          Show
          Sequences
          Orthology
          Comparative Orthology
          Alliance
          Gene Tree
          Ensembl
          Species Symbol Chromosome Accession # Evidence
          HumanAPOE19
          Conserved genome location (synteny) (2)
          Amino acid sequence comparison (2)
          MouseApoe7
          Amino acid sequence comparison (1)
          Citations
          1 - 10 of 41
          Show