Gene
ntrk2b
- ID
- ZDB-GENE-010126-2
- Name
- neurotrophic tyrosine kinase, receptor, type 2b
- Symbol
- ntrk2b Nomenclature History
- Previous Names
-
- trkB2 (1)
- si:ch211-220b11.1
- si:ch73-270f14.4
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have neurotrophin binding activity; neurotrophin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Involved in neuromast primordium migration. Predicted to localize to axon; integral component of plasma membrane; and receptor complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; early infantile epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Is expressed in gut and nervous system. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d0314 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
developmental and epileptic encephalopathy 58 | Alliance | Developmental and epileptic encephalopathy 58 | 617830 |
Obesity, hyperphagia, and developmental delay | 613886 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008266 | Tyrosine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Conserved_site | IPR002011 | Tyrosine-protein kinase, receptor class II, conserved site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
Domain | IPR003599 | Immunoglobulin domain subtype |
Domain | IPR007110 | Immunoglobulin-like domain |
Domain | IPR013098 | Immunoglobulin I-set |
Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
Family | IPR020777 | Growth factor receptor NTRK |
Family | IPR050122 | Receptor Tyrosine Kinase |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Repeat | IPR001611 | Leucine-rich repeat |
Domain Details Per Protein
Protein | Length | Growth factor receptor NTRK | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class II, conserved site |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A0R4ILA2
|
799 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
ntrk2b-201
(1)
|
Havana | 2616 nt | |
mRNA |
ntrk2b-202
(1)
|
Ensembl | 2563 nt |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-ntrk2 | polyclonal | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
13 | ||
Ab1-ntrk | polyclonal | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
3 |
Plasmids
No data available