Gene

ntrk2b

ID

ZDB-GENE-010126-2

Name

neurotrophic tyrosine kinase, receptor, type 2b

Symbol

ntrk2b Nomenclature History

Previous Names

trkB2 (1)
si:ch211-220b11.1
si:ch73-270f14.4

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor receptor activity. Acts upstream of or within neuromast primordium migration. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in gut and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

27 figures from 12 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cssl:d0314 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ntrk2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 58	Alliance	Developmental and epileptic encephalopathy 58	617830
		Obesity, hyperphagia, and developmental delay	613886

Associated With ntrk2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Conserved_site	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Family	IPR020777	Growth factor receptor NTRK
Family	IPR050122	Receptor Tyrosine Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily
Repeat	IPR001611	Leucine-rich repeat