Gene
ctsk
- ID
- ZDB-GENE-001205-4
- Name
- cathepsin K
- Symbol
- ctsk Nomenclature History
- Previous Names
-
- etID33526.16 (1)
- wu:fa95f03
- wu:fb08b05
- zgc:110367
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Acts upstream of or within bone development; cartilage development; and response to mechanical stimulus. Predicted to be located in apical plasma membrane and extracellular region. Predicted to be active in extracellular space and lysosome. Is expressed in several structures, including cardiovascular system; head; lateral line system; mesoderm; and pectoral fin. Human ortholog(s) of this gene implicated in pycnodysostosis. Orthologous to human CTSK (cathepsin K).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110367 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pycnodysostosis | Alliance | Pycnodysostosis | 265800 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR013201 | Cathepsin propeptide inhibitor domain (I29) |
| Domain | IPR039417 | Papain-like cysteine endopeptidase |
| Family | IPR013128 | Peptidase C1A |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | Cathepsin propeptide inhibitor domain (I29) | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine endopeptidase | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q568D6
|
333 |
Interactions and Pathways
No data available
Plasmids
No data available