Gene

adarb1a

ID

ZDB-GENE-000627-2

Name

adenosine deaminase RNA specific B1a

Symbol

adarb1a Nomenclature History

Previous Names

ADAR2 (1)
adarb1
RED1

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Involved in several processes, including embryonic cranial skeleton morphogenesis; lateral line development; and neural crest cell development. Predicted to localize to cytoplasm and nucleolus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Is expressed in several structures, including ceratobranchial cartilage; fin bud; nervous system; neural plate; and pericardial region. Orthologous to human ADARB1 (adenosine deaminase RNA specific B1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu111 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Li et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adarb1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with hypotonia, microcephaly, and seizures	618862

Associated With adarb1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002466	Adenosine deaminase/editase
Domain	IPR014720	Double-stranded RNA-binding domain
Domain	IPR044458	ADAR2, first double-stranded RNA binding domain
Domain	IPR044459	ADAR2, second double-stranded RNA binding domain