Gene
bmal1a
- ID
- ZDB-GENE-000509-1
- Name
- basic helix-loop-helix ARNT like 1a
- Symbol
- bmal1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Enables transcription cis-regulatory region binding activity. Contributes to DNA binding activity. Acts upstream of or within several processes, including photoperiodism; regulation of DNA-templated transcription; and regulation of vasculature development. Part of transcription regulator complex. Orthologous to human BMAL1 (basic helix-loop-helix ARNT like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55263 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Jensen et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ct803 | Allele with one deletion | Unknown | Unknown | zinc finger nuclease | |
| ihb734 | Allele with one deletion | Exon 11 | Unknown | CRISPR | |
| ihb735 | Allele with one deletion | Exon 11 | Unknown | CRISPR | |
| sa24645 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38044 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Circadian Clock Transcription Factors | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Nuclear translocator | PAC motif | PAS domain | PAS domain superfamily | PAS fold |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9I879
|
626 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arntl1a-201
(1)
|
Ensembl | 2,343 nt | ||
| mRNA |
arntl1a-202
(1)
|
Ensembl | 2,326 nt | ||
| mRNA |
arntl1a-203
(1)
|
Ensembl | 1,881 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-arntl1a | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-244M13 | ZFIN Curated Data | |
| Encodes | EST | fa04g03 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55263 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131577 (1) | 2343 nt | ||
| Genomic | GenBank:CR759966 (1) | 142946 nt | ||
| Polypeptide | UniProtKB:Q9I879 (1) | 626 aa |
- Chaigne, C., Sapède, D., Cousin, X., Sanchou, L., Blader, P., Cau, E. (2024) Contribution of the eye and of opn4xa function to circadian photoentrainment in the diurnal zebrafish. PLoS Genetics. 20:e1011172e1011172
- Godino-Gimeno, A., Leal, E., Chivite, M., Tormos, E., Rotllant, J., Vallone, D., Foulkes, N.S., Míguez, J.M., Cerdá-Reverter, J.M. (2024) Role of melanocortin system in the locomotor activity rhythms and melatonin secretion as revealed by agouti-signalling protein (asip1) overexpression in zebrafish. Journal of pineal research. 76:e12939e12939
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Aranda-Martínez, P., Fernández-Martínez, J., Ramírez-Casas, Y., Rodríguez-Santana, C., Rusanova, I., Escames, G., Acuña-Castroviejo, D. (2023) Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment. Antioxidants (Basel, Switzerland). 12(4):
- D'Agostino, Y., Frigato, E., Noviello, T.M.R., Toni, M., Frabetti, F., Cigliano, L., Ceccarelli, M., Sordino, P., Cerulo, L., Bertolucci, C., D'Aniello, S. (2022) Loss of circadian rhythmicity in bdnf knockout zebrafish larvae. iScience. 25:104054
- Dao, P., Hajny, S., Mekis, R., Orel, L., Dinhopl, N., Tessmar-Raible, K., Nowikovsky, K. (2022) The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish. Life science alliance. 5(9)
- Bolton, C.M., Bekaert, M., Eilertsen, M., Helvik, J.V., Migaud, H. (2021) Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain. Frontiers in Physiology. 12:761109
- Safarian, N., Houshangi-Tabrizi, S., Zoidl, C., Zoidl, G.R. (2021) Panx1b Modulates the Luminance Response and Direction of Locomotion in the Zebrafish. International Journal of Molecular Sciences. 22(21):
- Zheng, X., Zhang, K., Zhao, Y., Fent, K. (2021) Environmental chemicals affect circadian rhythms: An underexplored effect influencing health and fitness in animals and humans. Environment International. 149:106159
- Kelu, J.J., Pipalia, T.G., Hughes, S.M. (2020) Circadian regulation of muscle growth independent of locomotor activity. Proceedings of the National Academy of Sciences of the United States of America. 117(49):31208-31218
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