Gene
dazl
- ID
- ZDB-GENE-000405-6
- Name
- deleted in azoospermia-like
- Symbol
- dazl Nomenclature History
- Previous Names
-
- zDAZL
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Enables mRNA 3'-UTR binding activity; sequence-specific DNA binding activity; and translation activator activity. Acts upstream of or within 3'-UTR-mediated mRNA stabilization and negative regulation of miRNA-mediated gene silencing. Located in cytoplasm. Is expressed in blastodisc; gonad; male organism; unfertilized egg; and yolk. Orthologous to several human genes including DAZL (deleted in azoospermia like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 42 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Bertho et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ae34 | Allele with one delins | Exon 6 | Inframe Deletion | CRISPR | |
| ae57 | Allele with one delins | Exon 6 | Premature Stop | CRISPR | |
| la028012Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mu12 | Allele with one delins | Unknown | Frameshift, Premature Stop | zinc finger nuclease |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Spermatogenic failure, susceptibility to} |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR037551 | DAZ, RNA recognition motif, vertebrates |
| Domain | IPR043628 | DAZ domain |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Length | DAZ domain | DAZ, RNA recognition motif, vertebrates | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q9YGW7
|
229 | |||||
|
UniProtKB:Q1LUN6
|
229 | |||||
|
UniProtKB:A0A8M2BHE4
|
212 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-195K18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-146H10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:100774 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131524 (1) | 2166 nt | ||
| Genomic | GenBank:BX927400 (2) | 172655 nt | ||
| Polypeptide | UniProtKB:Q1LUN6 (1) | 229 aa |
- Chu, W.K., Huang, S.C., Chang, C.F., Wu, J.L., Gong, H.Y. (2023) Infertility control of transgenic fluorescent zebrafish with targeted mutagenesis of the dnd1 gene by CRISPR/Cas9 genome editing. Frontiers in genetics. 14:10292001029200
- McConnell, S.C., Hernandez, K.M., Andrade, J., de Jong, J.L.O. (2023) Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes. Scientific Reports. 13:77777777
- Wang, X., Zhu, J., Wang, H., Deng, W., Jiao, S., Wang, Y., He, M., Zhang, F., Liu, T., Hao, Y., Ye, D., Sun, Y. (2023) Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors. Nature communications. 14:79187918
- Doretto, L.B., Butzge, A.J., Nakajima, R.T., Martinez, E.R.M., de Souza, B.M., Rodrigues, M.D.S., Rosa, I.F., Ricci, J.M.B., Tovo-Neto, A., Costa, D.F., Malafaia, G., Shao, C., Nóbrega, R.H. (2022) Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners. Cells. 11(8):
- Qian, P., Kang, J., Liu, D., Xie, G. (2022) Single Cell Transcriptome Sequencing of Zebrafish Testis Revealed Novel Spermatogenesis Marker Genes and Stronger Leydig-Germ Cell Paracrine Interactions. Frontiers in genetics. 13:851719
- Rodrigues, M.S., Tovo-Neto, A., Rosa, I.F., Doretto, L.B., Fallah, H.P., Habibi, H.R., Nóbrega, R.H. (2022) Thyroid Hormones Deficiency Impairs Male Germ Cell Development: A Cross Talk Between Hypothalamic-Pituitary-Thyroid, and-Gonadal Axes in Zebrafish. Frontiers in cell and developmental biology. 10:865948
- Tao, B., Hu, H., Chen, J., Chen, L., Luo, D., Sun, Y., Ge, F., Zhu, Z., Trudeau, V.L., Hu, W. (2022) Sinhcaf-dependent histone deacetylation is essential for primordial germ cell specification. EMBO reports. 23(6):e54387
- Bertho, S., Clapp, M., Banisch, T.U., Bandemer, J., Raz, E., Marlow, F.L. (2021) Zebrafish dazl regulates cystogenesis and germline stem cell specification during the primordial germ cell to germline stem cell transition. Development (Cambridge, England). 148(7)
- Dai, X., Cheng, X., Huang, J., Gao, Y., Wang, D., Feng, Z., Zhai, G., Lou, Q., He, J., Wang, Z., Yin, Z. (2021) Rbm46, a novel germ cell specific factor, modulates meiotic progression and spermatogenesis. Biology of reproduction. 104(5):1139-1153
- D'Orazio, F.M., Balwierz, P.J., González, A.J., Guo, Y., Hernández-Rodríguez, B., Wheatley, L., Jasiulewicz, A., Hadzhiev, Y., Vaquerizas, J.M., Cairns, B., Lenhard, B., Müller, F. (2021) Germ cell differentiation requires Tdrd7-dependent chromatin and transcriptome reprogramming marked by germ plasm relocalization. Developmental Cell. 56(5):641-656.e5
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