Gene
anos1a
- ID
- ZDB-GENE-000201-9
- Name
- anosmin 1a
- Symbol
- anos1a Nomenclature History
- Previous Names
-
- anosmin-1a (1)
- kal1a
- kal1.1
- wu:fl91z45
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable peptidase inhibitor activity. Acts upstream of or within neuron differentiation; olfactory bulb development; and posterior lateral line development. Predicted to be located in extracellular region. Predicted to be active in cell surface. Is expressed in several structures, including digestive system; nervous system; neural tube; otic vesicle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 1 with or without anosmia. Orthologous to human ANOS1 (anosmin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73357 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 1 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 1 with or without anosmia (Kallmann syndrome 1) | 308700 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Anosmin-1 | Anosmin-1, cysteine rich domain | Elafin-like superfamily | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | WAP-type 'four-disulfide core' domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9IAR4
|
652 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
anos1a-201
(1)
|
Ensembl | 2,392 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-anos1a | polyclonal | Rabbit |
|
3 | |||
| Ab2-anos1a | polyclonal | Rabbit |
|
3 |
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Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-157N19 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-148E3 | ZFIN Curated Data | |
| Encodes | EST | fl91z45 | ||
| Encodes | cDNA | MGC:73357 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131358 (1) | 2854 nt | ||
| Genomic | GenBank:BX901898 (1) | 249378 nt | ||
| Polypeptide | UniProtKB:Q9IAR4 (1) | 652 aa |
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Wang, J., Yin, Y., Lau, S., Sankaran, J., Rothenberg, E., Wohland, T., Meier-Schellersheim, M., Knaut, H. (2018) Anosmin1 Shuttles Fgf to Facilitate Its Diffusion, Increase Its Local Concentration, and Induce Sensory Organs. Developmental Cell. 46(6):751-766.e12
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wang, F., Huang, G.D., Tian, H., Zhong, Y.B., Shi, H.J., Li, Z., Zhang, X.S., Wang, H., Sun, F. (2015) Point mutations in KAL1 and the mitochondrial gene MT-tRNA(cys) synergize to produce Kallmann syndrome phenotype. Scientific Reports. 5:13050
- Miyasaka, N., Wanner, A.A., Li, J., Mack-Bucher, J., Genoud, C., Yoshihara, Y., and Friedrich, R.W. (2013) Functional development of the olfactory system in zebrafish. Mechanisms of Development. 130(6-8):336-46
- Ayari, B., Landoulsi, A., and Soussi-Yanicostas, N. (2012) Localization and characterization of kal 1.a and kal 1.b in the brain of adult zebrafish (Danio rerio). Brain research bulletin. 88(4):345-353
- Hensley, M.R., Emran, F., Bonilla, S., Zhang, L., Zhong, W., Grosu, P., Dowling, J.E., and Leung, Y.F. (2011) Cellular Expression of Smarca4 (Brg1)-regulated Genes in Zebrafish Retinas. BMC Developmental Biology. 11(1):45
- Rissone, A., Sangiorgio, L., Monopoli, M., Beltrame, M., Zucchi, I., Bussolino, F., Arese, M., and Cotelli, F. (2010) Characterization of the neuroligin gene family expression and evolution in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(2):688-702
- Yanicostas, C., Herbomel, E., Dipietromaria, A., and Soussi-Yanicostas, N. (2009) Anosmin-1a is required for fasciculation and terminal targeting of olfactory sensory neuron axons in the zebrafish olfactory system. Molecular and Cellular Endocrinology. 312(1-2):53-60
- Yanicostas, C., Ernest, S., Dayraud, C., Petit, C., and Soussi-Yanicostas, N. (2008) Essential requirement for zebrafish anosmin-1a in the migration of the posterior lateral line primordium. Developmental Biology. 320(2):469-479
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