Gene
anos1b
- ID
- ZDB-GENE-000201-13
- Name
- anosmin 1b
- Symbol
- anos1b Nomenclature History
- Previous Names
-
- anosmin-1b (1)
- kal1b
- kal1.2
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable peptidase inhibitor activity. Acts upstream of or within posterior lateral line neuromast deposition. Predicted to be located in extracellular region. Predicted to be active in cell surface. Is expressed in several structures, including brain; hair cell; sensory system; tail bud; and vertical myoseptum. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 1 with or without anosmia. Orthologous to human ANOS1 (anosmin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028461Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa24225 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sk52 | Allele with one deletion | Unknown | Unknown | TALEN | |
| sk53 | Allele with one deletion | Unknown | Unknown | TALEN |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 1 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 1 with or without anosmia (Kallmann syndrome 1) | 308700 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Anosmin-1 | Anosmin-1, cysteine rich domain | Elafin-like superfamily | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | WAP-type 'four-disulfide core' domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1MT36
|
633 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
anos1b-201
(1)
|
Ensembl | 4,346 nt | ||
| mRNA |
anos1b-202
(1)
|
Ensembl | 3,136 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:anos1b) |
|
| 1 | Wang et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-258L4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131379 (1) | 4346 nt | ||
| Genomic | GenBank:AL953867 (1) | 177575 nt | ||
| Polypeptide | UniProtKB:Q1MT36 (1) | 633 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | ANOS1 | X | Amino acid sequence comparison (2) |
- Wang, J., Yin, Y., Lau, S., Sankaran, J., Rothenberg, E., Wohland, T., Meier-Schellersheim, M., Knaut, H. (2018) Anosmin1 Shuttles Fgf to Facilitate Its Diffusion, Increase Its Local Concentration, and Induce Sensory Organs. Developmental Cell. 46(6):751-766.e12
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wang, F., Huang, G.D., Tian, H., Zhong, Y.B., Shi, H.J., Li, Z., Zhang, X.S., Wang, H., Sun, F. (2015) Point mutations in KAL1 and the mitochondrial gene MT-tRNA(cys) synergize to produce Kallmann syndrome phenotype. Scientific Reports. 5:13050
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Ayari, B., Landoulsi, A., and Soussi-Yanicostas, N. (2012) Localization and characterization of kal 1.a and kal 1.b in the brain of adult zebrafish (Danio rerio). Brain research bulletin. 88(4):345-353
- Yanicostas, C., Herbomel, E., Dipietromaria, A., and Soussi-Yanicostas, N. (2009) Anosmin-1a is required for fasciculation and terminal targeting of olfactory sensory neuron axons in the zebrafish olfactory system. Molecular and Cellular Endocrinology. 312(1-2):53-60
- Yanicostas, C., Ernest, S., Dayraud, C., Petit, C., and Soussi-Yanicostas, N. (2008) Essential requirement for zebrafish anosmin-1a in the migration of the posterior lateral line primordium. Developmental Biology. 320(2):469-479
- Ernest, S., Guadagnini, S., Prevost, M.C., and Soussi-Yanicostas, N. (2007) Localization of anosmin-1a and anosmin-1b in the inner ear and neuromasts of zebrafish. Gene expression patterns : GEP. 7(3):274-281
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Whitlock, K.E., Illing, N., Brideau, N.J., Smith, K.M., and Twomey, S. (2006) Development of GnRH cells: Setting the stage for puberty. Molecular and Cellular Endocrinology. 254-255:39-50
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