FIGURE

Fig. 3

ID

ZDB-FIG-240718-55

Publication

LaCoursiere et al., 2024 - Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

A dose-dependent decrease in the number of interneurons in a subset of zebrafish mutant lines, arfgerf1 and wnt8b (A) Schematic representation of larval zebrafish brain gross anatomy highlighting the optic tectum. (B) Exemplary images of arfgef1 and wnt8b mutant allele combinations. (C) Dose-dependent decrease in inhibitory interneurons in arfgef1 and wnt8b mutants compared to WT sibling controls. tel, telencephalon; teO, optic tectum; hb, hindbrain. Arfgef1 WT: n = 10, HET: n = 15, HOM n = 6; wnt8b WT: n = 11, HET: n = 18, HOM n = 8 Statistical significance was determined by Kruskal-Wallis test with Dunnett’s multiple comparisons, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. Data are represented as median ±1.5∗IQR. Scale bar is 200 μm. Additional information available in Table S3 .

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ iScience