FIGURE

Figure 7

ID

ZDB-FIG-240613-48

Publication

D'Gama et al., 2024 - Ciliogenesis defects after neurulation impact brain development and neuronal activity in larval zebrafish

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Figure 7

Reduced ongoing spontaneous activity and correlation in the elipsa mutants

(A1–A4) Three-dimensional representation of segmented neurons and their activity for one representative control and elipsa for the Telencephalon (A1), Habenula (A2), TeO/thalamus (A3) and Hindbrain (A4). Dark color represents higher dF/F signals.

(B1–B4) Average cumulative frequency distribution graphs showing the percentage of activity of neurons in Telencephalon (B1), Habenula (B2), TeO/thalamus (B3) and Hindbrain (B4), for control (black) and elipsa (cyan). (+/− standard error of mean as the shaded area). Dotted lines indicate activity below 10% and above 50%.

(C1–C4) Mean Pearson’s correlation versus distance graphs showing positive and negative correlation between cells in Telencephalon (C1), Habenula (C2), TeO/thalamus (C3) and Hindbrain (C4), for control (black) and mutant (cyan). Significance tests for the correlation were computed for cells located within 60 μm indicated by the dotted line on the X axis. ∗: p < 0.05, ∗∗: p < 0.01, ∗∗∗: p < 0.001 according to Wilcoxon Rank-Sum test. n = 10 controls and 11 mutants.

See also Figure S5.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	traf3ip1^tp49d/tp49d; jf7Tg
Observed In:	habenula regulation of neuronal action potential hindbrain regulation of neuronal action potential optic tectum regulation of neuronal action potential telencephalon regulation of neuronal action potential
Stage:	Day 4

Phenotype Detail

Acknowledgments

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