Figure 2

Swim speed analysis of F1 adult zebrafish expressing mutant human lamin A/C with those expressing WT human lamin A/C. (A–C) Swim speed analysis of F1 adult fish using T-maze behavior. The red plot represents AB(WT) fish, orange plot represents LMNA(WT) fish, green plot represents LMNA(L35P) fish, brown plot for LMNA(E358K) fish, blue plot for LMNA(R453W) fish, purple plot for LMNA(W520G) fish, and black plot for LMNA(A539V) fish. Each dot represents one fish. AB(WT): n = 6; LMNA(WT): n = 6; LMNA(L35P): n = 6; LMNA(E358K): n = 5; LMNA(R453W): n = 3; LMNA(A539V): n = 4. Statistical analysis was performed using ordinary One-way ANOVA comparing the mean of each column with the mean of control column (LMNA(WT)), and corrected for multiple comparisons using Dunnett’s test. The presented p-values have been appropriately adjusted, and the level of statistical significance is indicated by the following notation: *0.01 < P ≤ 0.05; **0.001 < P ≤ 0.01; ***0.0001 < P ≤ 0.001; ****P ≤ 0.0001.