FIGURE

Fig. 2

ID

ZDB-FIG-240515-19

Publication

Juliana et al., 2024 - Characterization of the zebrafish as a model of ATP-sensitive potassium channel hyperinsulinism

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Fig. 2

Zebrafish larvae pancreatic islet cytoplasmic Ca2+ measurements. (A) Measurement of zebrafish pancreatic islet cytosolic Ca2+ fluorescence in abcc8+/+ control (95% CI 8.4×104, 8.8×104) and abcc8-/- (95% CI 1.1×105, 1.2×105) zebrafish larvae (5 dpf) (p=0.0216, n=8–10). (B) Zebrafish larvae pancreatic islet cytosolic Ca2+ measurements in response to glucose stimulation in abcc8-/- (95% CI 1.6×105, 1.7×105) and control abcc8+/+ (95 % CI 1.4×105, 1.6×105) larvae (p=0.51, n=8–10). (C) Assessment of zebrafish larvae pancreatic islet cytosolic Ca2+ in response to glutamine in abcc8+/+ control (95% CI 9.7×104, 1×105), and abcc8-/- (95% CI 1.32×105, 1.38×105) larvae (p=0.0486, n=8–10). (D) Area under the curve calculations for cytoplasmic Ca2+ experiments as denoted. *p<0.05. Data represent mean±SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	abcc8^{sa15863/sa15863}; ml110Tg
Condition:	chemical treatment by injection: glutamine
Observed In:	endocrine pancreas calcium(2+)
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMJ Open Diabetes Res Care