Fig. 5
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- ZDB-FIG-240416-59
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- Ghosh et al., 2024 - A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression
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Phylogenetic relationship of RNLTR12-int and Mbp (A) Common tree display represents a hierarchical view of evolutionary relationships among taxa and their lineages. Appearance of myelin/MBP is associated with the gain of hinge-jaw in vertebrates1–3, 6. Presence of myelin/MBP1–3, 6 in most ancient living vertebrate (the cartilaginous fishes) (red dotted horizontal line) to higher vertebrates (red dotted vertical line) is marked. Black dotted vertical line marks the vertebrate classes wherever RetroMyelin is identified in our study. All identified RetroMyelin belong to the ERV1 family, carrying internal sequence of ERV1. (B) Expressed sequence tags (ESTs) were aligned to the RetroMyelin sequence of human, mouse, rats, zebrafish, Xenopus laevis, and elephant sharks. BLASTn was used to search ESTs. For the displayed ESTs: 0 < E value < 2.9e−18 and 100 < alignment score < 2,298. For human, mouse, rat, and zebrafish: consensus sequence was used. For elephant shark and Xenopus laevis: the best hit obtained after nhmmer search on RNLTR12-int (Table S1; see STAR Methods) was used. Magenta: alignment score ≥ 100, red: alignment score ≥ 200. See also Table S1. |
Reprinted from Cell, 187, Ghosh, T., Almeida, R.G., Zhao, C., Mannioui, A., Martin, E., Fleet, A., Chen, C.Z., Assinck, P., Ellams, S., Gonzalez, G.A., Graham, S.C., Rowitch, D.H., Stott, K., Adams, I., Zalc, B., Goldman, N., Lyons, D.A., Franklin, R.J.M., A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression, 814830.e23814-830.e23, Copyright (2024) with permission from Elsevier. Full text @ Cell