FIGURE

Fig. 1

ID

ZDB-FIG-240401-11

Publication

Neil et al., 2024 - Determining Photoreceptor Cell Identity: Rod Versus Cone Fate Governed by tbx2b Opposing nrl

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Fig. 1

The nrl and tbx2b mutants have strikingly opposite effects on rod and sws1 cone developmental phenotypes. (A, B) Schematics highlighting that the role of Nrl in patterning the rod fate in mouse models is recapitulated and expanded upon in the zebrafish model. (C) Previous research has established that nrl mutants exhibit a dramatic loss of rod cell development and a concomitant increase of short-wavelength cones (mice and zebrafish),13,15 whereas the opposite is observed in tbx2b mutants (zebrafish).25 We seek to resolve whether this relation between the rod and UV cone fates represents a single fate determination mechanism, or two independent mechanisms governing each cell fate.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Invest. Ophthalmol. Vis. Sci.