FIGURE

Fig. 1

ID

ZDB-FIG-240103-1

Publication

Lin et al., 2024 - RPTOR blockade suppresses brain metastases of NSCLC by interfering the ceramide metabolism via hijacking YY1 binding

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Fig. 1

Association of high RPTOR expression or the ceramide pathway with NSCLC-BM. A, B RNA sequencing showed that RPTOR was more highly expressed in BM than other genes like PLP1, GFAP, TF, PMP2 and TUBB4A, which was validated by qRT-PCR. C, D IHC analysis showed that the BM + group reported a higher RPTOR expression and score than the BM- group (100x, 200 × magnification, scale bar = 100 μm). E Kaplan–Meier analysis showed that the median survival was significantly lower in the high RPTOR (18 samples with IHC scores ≥ 6) than in the low RPTOR subgroup (15 samples with IHCs ≤ 3) in the BM + patients. F, G H1299 and PC9 cell lines were chosen to be our experiment cell lines due to their significantly higher RPTOR expression than those in other LUAD cell lines. H, I The whole-exome sequencing (WES) was used to screen different genes from the BM + and BM- groups. A DAGM model was constructed to assess the role of somatic variants in the signaling pathways. The ceramide signaling pathway was found to be involved in the BM progress

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Exp. Clin. Cancer Res.