FIGURE

Fig. 6.

ID

ZDB-FIG-231126-6

Publication

Bravo et al., 2023 - Macrophage activation drives ovarian failure and masculinization in zebrafish

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Fig. 6.

Il34 and Csf1a differentially contribute to ovarian failure and sex reversal and macrophages persist in csf1a- and il34-mutant ovaries.

(A and B) Live tissue images of adult gonads of indicated genotypes. Scale bar, 500 μm. (C) Graph with adult sex ratios of indicated genotypes. Female, pink; male, blue. Numbers indicate individuals examined. Statistical analysis: chi-square test with Bonferroni correction; P value comparisons to bmp15^+/−, ***P ≤ 0.0001. (D to O) Immunostained adult gonads of (E) to (J) ligand single mutants, and (K) to (O) bmp15;ligand DMs of indicated genotypes. Aif1l (yellow) labels macrophages, Ddx4 (magenta) labels germ cells, and DAPI (blue) labels DNA. Dotted lines mark macrophages. Scale bars, 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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