FIGURE

Fig. 1.

ID

ZDB-FIG-231002-105

Publication

Leid et al., 2023 - Deletion of taf1 and taf5 in zebrafish capitulate cardiac and craniofacial abnormalities associated with TAFopathies through perturbations in metabolism

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1.

corast^l325/stl325 embryos display reduced survival and heart failure. (A) Light microscopy showing the emergence of pericardial edema between 72 and 120 h post fertilization (hpf). P, pericardium; H, heart. Phenotype ratios are presented on the right. (number of trials=4; number of samples per trial=48) (B) Survival curve of cora^stl325 embryos relative to their unaffected clutchmates (number of trials=4; number of samples per trial=48). (C) Quantification of light microscopy images measuring area of the pericardium (number of trials=4; number of samples per trial=48). (D) Quantification of light microscopy images measuring ejection fraction (number of trials=4; number of samples per trial=48). (E) Lightsheet microscopy generated images of 96 hpf embryos harboring the cmlc::GFP transgenic reporter. Hearts are shown in systole and diastole. A, atrium; V, ventricle. Quantification of ejection fraction (n=4). (F) Quantification of changes in cell dimension using lightsheet-generated videos (n=4).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	taf5^{stl325/stl325} taf5^{stl325/stl325}; twu34Tg
Observed In:	heart heart contraction pericardium whole organism
Stage Range:	Day 4 to Days 14-20

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biol. Open