FIGURE

Fig. 7

ID

ZDB-FIG-230912-21

Publication

Mathavarajah et al., 2023 - PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

Overview of the suppression of LINE-1 retrotransposition in jawed vertebrates through the collective functions of PML, Plex9 and TREX1 enzymes. In fish, PML and novel Plex9 enzymes play a major role in suppressing both LINE-1 and LINE-2 elements. Despite the loss of PML in Teleost fish genomes, they have retained Plex9 genes for the purpose of restricting LINE retrotransposition. TREX1 appears later in tetrapods, where Plex9 genes are lost. In addition, enzymatic PML function is lost and the protein forms nuclear bodies rather than localizing to the cytoplasm. However, PML has a retained an exonuclease-independent role for the surveillance of LINEs by shuttling to the cytoplasm to suppress the LINE1 retrotransposition. Thus, the three protein families (PML, Plex9 and TREX) share an important function in maintaining genome integrity in jawed vertebrates by repressing LINE-1 propagation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nucleic Acids Res.