FIGURE
Fig. 7
- ID
- ZDB-FIG-230816-13
- Publication
- Légaré et al., 2023 - Loss of mitochondrial Chchd10 or Chchd2 in zebrafish leads to an ALS-like phenotype and Complex I deficiency independent of the mitochondrial integrated stress response
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Fig. 7
Reduced assembly of mitochondrial Complex I in chchd10−/− and chchd2−/− zebrafish larvae, but not in double chchd10−/− and chchd2−/− larvae at 5 dpf. (a) Immunoblot analysis of mitochondrial respiratory chain subunits in larvae aged 5 dpf and quantification (b). Ndufa9 is significantly reduced in chchd10−/− larvae (p = .003). Data is represented as mean ± SEM. Sample sizes (n) are noted in parentheses. (c) Representative blue native PAGE with each lane constituted of an individual 5 dpf larvae of respective genotype and quantification (d). Significant reduction of Complex I assembly was observed in chchd10−/− larvae (p = .003), and chchd2−/− larvae (p = .044), but not in double chchd10−/− and chchd2−/− model (p = .990). Significance was assessed using a one-way ANOVA and Tuckey's multiple comparison test, and significant differences from wild type larvae are represented by either a single asterisk (p < .05) or double asterisk (p < .01). Data is represented as mean ± SEM. Sample sizes (n) are noted in parentheses.
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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