Fig. 3

DEPICT results for gene-set and cell/tissue enrichment analyses.

a Meta gene-sets were defined from similarity clustering of significantly enriched gene sets (FDR < 5%). Each Meta gene-set was named after one of its member gene-sets. The color of the Meta gene-sets represents the P value of the member set. Interconnection line width represents the Pearson correlation ρ between the gene membership scores for each Meta gene-set (ρ < 0.3, no line; 0.3 ≤ρ < 0.45, narrow width; 0.45 ≤ρ < 0.65, medium width; ρ ≥ 0.65, thick width). b Bars represent the level of evidence for genes in the associated loci to be expressed in any of the 209 Medical Subject Heading (MeSH) tissue and cell type annotations. Highlighted in orange are these cell/tissue types significantly (FDR < 5%) enriched for the expression of the genes in the associated loci.