Schematic diagram illustrating the primary structure of FLRT2 adapted fromFlintoff et al., 2014andLacy et al., 1999. The extracellular domain contains 10 Leucine Rich Repeat sequences flanked by N- and C- terminal cysteine-rich regions. The FNIII domain lies closer to the cell membrane. These proteins span the cell membrane once and have a short cytoplasmic tail. SS: signal sequence; NFR: cysteine-rich domains flanking N′ terminal ends of LRR domain; LRR: 10 leucine-rich repeats; CFR: cysteine-rich domains flanking C′ terminal ends of LRR domain; FN: fibronectin III domain; TM: transmembrane domain; IC: cytoplasmic tail.
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