FIGURE

FIGURE 4

ID

ZDB-FIG-230429-4

Publication

Vedder et al., 2023 - pyHeart4Fish: Chamber-specific heart phenotype quantification of zebrafish in high-content screens

Other Figures

All Figure Page

Back to All Figure Page

FIGURE 4

Quantitative data analysis with pyHeart4Fish. Analysis of treated fish with pyHeart4Fish revealed multiple functional heart phenotypes. (A) The left graph presents the detected heart rate derived from the fast fourier transformation (FFT). The right graph displays the approximate heart size in µm². (B) Percentual data on the severity of manually assessed pericardial edema in treated Tg(myl7:eGPF)^twu34/+ zebrafish. (C) The relative contractility derived from percentual size changes of each heart chamber (left graph). Approximate ejection fraction determined by chamber volume changes (right graph). (D) Mean max. heart chamber size (dilation) is presented on the left, while the mean min. heart chamber size (max. contraction) is displayed on the right. The number of fish analyzed is shown in brackets after the treatment condition. Dotted gray lines indicate z-scores of ±1.96 and statistical significance with an alpha error of 5%.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol