FIGURE

Figure 4

ID

ZDB-FIG-230407-4

Publication

Grdseloff et al., 2023 - Impaired retinoic acid signaling in cerebral cavernous malformations

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Figure 4

Assessment of KLF2/4 mRNA expression in treated animal models of CCM. (a) Expression levels of treated BECiCcm2 mouse cerebella after curative RA treatment (~ 20 mg/kg/day for 21 days) as mean fold changes determined by qRT-PCR. (ns = P > 0.05; **P < 0.01;***P < 0.001;****P < 0.0001 vs. control). Each data point represents one sample. Error bars show mean with SD. (b) Fold changes of KLF2/4 mRNA expression in siCCM2-transfected HUVECs treated with RA for 48 h compared to untreated cells (*P < 0.05; **P < 0.01). Each data point represents one sample. (c) Whole-mount in situ hybridization of klf2a in 48 hpf zebrafish embryos treated with DMSO or Talarozole.

Expression Data

Gene:	klf2a
Fish:	WT krit1^{ty219c/ty219c}
Condition:	chemical treatment by environment: talarozole
Anatomical Term:	heart
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	krit1^{ty219c/ty219c}
Condition:	chemical treatment by environment: talarozole
Observed In:	heart
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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