FIGURE

Fig. 6

ID

ZDB-FIG-230330-7

Publication

Huang et al., 2022 - De novo establishment of circuit modules restores locomotion after spinal cord injury in adult zebrafish

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Fig. 6

Figure 6. Individual physical training facilitated axon regrowth of slow V2a interneurons and accelerated spontaneous locomotor restoration

(A) Physical training protocol for SCI animals from 2 to 4 wpi.

(B) Quantification of free-swimming speed, maximum-swimming speed, and numbers of V2a interneurons with regrown axons in four spinal segments rostral to the injury site in the training and non-training groups at 4 wpi as well as in the uninjured group. One dot equals one fish.

(C) Left: RD labeling of propriospinal V2a interneurons with descending axon regrowing over the injury site in the training and non-training groups at 4 wpi. Right: somata location of propriospinal V2a interneurons with regrown axons along the dorsoventral and mediolateral aspects of the spinal cord in the training and non-training groups at 4 wpi. One dot equals one neuron. N = 3 fish and four segments immediately rostral to the lesion were measured in each fish. All data are presented as mean ± SD. ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001, significant difference.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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