FIGURE

Fig. 6

ID

ZDB-FIG-230317-9

Publication

Smith et al., 2021 - Lysosomes and the pathogenesis of merosin-deficient congenital muscular dystrophy

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Fig. 6

Increasing lysosomal biogenesis moderately protects against myofiber detachment in caf zebrafish. (A) Lysosomal biogenesis transcription factor TFEB increases the number of lysosomes in myofibers, however not significantly (P = 0.1200). (B) Confocal micrographs illustrating GFP-expressing myofibers in WT embryos. (C) Confocal micrographs illustrating GFP-expressing myofibers in caf mutant embryos (detached fibers: TFEB-GFP = 33.9%; PLCδ-PH-GFP = 45.4%; P = 0.0065).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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