FIGURE

Fig 1

ID

ZDB-FIG-230315-51

Publication

Xie et al., 2023 - Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish

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Fig 1

Mutation of ccdc57 leads to scoliosis.

(A) Representative images of male and female wild type and tft^168N mutants. (B) Micro-CT images showing lateral and dorsal views of 3-months-old wild type and tft^168N mutants. (C) Genomic structure and sequences of wild type, tft^168N mutant and two ccdc57 mutant alleles generated with CRISPR/Cas9. The underlined sequence in wt indicates PAM sequence of sgRNA target. (D) Representative images of male and female wild type and ccdc57 mutants with different genetic background as indicated. (E) The dissected brain and spinal cord in wild type and ccdc57 mutant. Scale bars: 1 cm in panels A, B, D, E.

Expression Data

Expression Detail

No data available

Antibody Labeling

No data available

Phenotype Data

Fish:	ccdc57^{ouc2033/ouc2033} ccdc57^{ouc2034/ouc2034} ccdc57^{tft168N/tft168N} ccdc57^tft168N/+; ccdc57^ouc2034/+
Observed In:	spinal cord vertebra vertebral column
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Biol.